Search Results

Overview

Uniprot ID	F6ZDS4
Protein Name	Nucleoprotein TPR
Gene Name	Tpr
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
1718	QQRQITLKTTPASGE

Function

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Plays a limited role in the regulation of nuclear protein export. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases (By similarity)

Protein Sequence

10 MTSGGSASRS 20 GHRGVPMTSR 30 GFDGSRRGSL 40 RRAGARETAS 50 EAADGAAPAA 60 GLRASPCSLA 70 SPSAAAAVAA 80 IPADMAAVLQ 90 QVLERPELNK 100 LPKSTQNKLE 110 KFLAEQQSEI 120 DCLKGRHEKF 130 KVESEQQYFE 140 IEKRLSQSQE 150 RLVTETRECQ 160 NLRLELEKLN 170 NQVKVLTEKT 180 KELETAQDRN 190 LGIQSQFTRA 200 KEELEAEKRD 210 LIRTNERLSQ 220 EVEYLTEDVK 230 RLNEKLKESN 240 TTKGELQLKL 250 DELQASDVAV 260 KYREKRLEQE 270 KELLHNQNSW 280 LNTELKTKTD 290 ELLALGREKG 300 NEILELKCNL 310 ENKKEEVLRL 320 EEQMNGLKTS 330 NEHLQKHVED 340 LLTKLKEAKE 350 QQASMEEKFH 360 NELNAHIKLS 370 NLYKSAADDS 380 EAKSNELTRA 390 VDELHKLLKE 400 AGEANKTIQD 410 HLLQVEESKD 420 QMEKEMLEKI 430 GKLEKELENA 440 NDLLSATKRK 450 GAILSEEELA 460 AMSPTAAAVA 470 KIVKPGMKLT 480 ELYNAYVETQ 490 DQLLLEKQEN 500 KRINKYLDEI 510 VKEVEAKAPI 520 LKRQREEYER 530 AQKAVASLSA 540 KLEQAMKEIQ 550 RLQEDTDKAN 560 KHSSVLERDN 570 QRMEIQIKDL 580 SQQIRVLLME 590 LEEARGNHVI 600 RDEEVSSADI 610 SSSSEVISQH 620 LVSYRNIEEL 630 QQQNQRLLFA 640 LRELGETRER 650 EEQETTSSKI 660 AELQHKLENS 670 LAELEQLRES 680 RQHQMQLVDS 690 IVRQRDMYRI 700 LLSQTTGMAI 710 PLQASSLDDI 720 SLLSTPKRSS 730 TSQTVSTPAP 740 EPVIDSTEAI 750 EAKAALKQLQ 760 EIFENYKKEK 770 IDSEKLQNEQ 780 LEKLQEQVTD 790 LRSQNTKIST 800 QLDFASKRYE 810 MLQDNVEGYR 820 REITSLQERN 830 QKLTATTQKQ 840 EQIINTMTQD 850 LRGANEKLAV 860 AEVRAENLKK 870 EKEMLKLSEV 880 RLSQQRESLL 890 AEQRGQNLLL 900 TNLQTIQGIL 910 ERSETETKQR 920 LNSQIEKLEH 930 EISHLKKKLE 940 NEVEQRHTLT 950 RNLDVQLLDT 960 KRQLDTEINL 970 HLNTKELLKN 980 AQKDIATLKQ 990 HLNNMEAQLA 1000 SQSTQRTGKG 1010 QPGDRDDVDD 1020 LKSQLRQAEE 1030 QVNDLKERLK 1040 TSTSNVEQYR 1050 AMVTSLEDSL 1060 NKEKQVTEEV 1070 HKNIEVRLKE 1080 SAEFQTQLEK 1090 KLMEVEKEKQ 1100 ELQDDKRKAI 1110 ESMEQQLSEL 1120 KKTLSTVQNE 1130 VQEALQRAST 1140 ALSNEQQARR 1150 DCQEQAKIAV 1160 EAQNKYEREL 1170 MLHAADVEAL 1180 QAAKEQVSKM 1190 TSIRQHLEET 1200 TQKAESQLLE 1210 CKASWEERER 1220 VLKDEVSKSV 1230 SRCEDLEKQN 1240 RLLHDQIEKL 1250 SDKVVTSMKD 1260 AVQAPLNVSL 1270 NEEGKSQEQI 1280 LEILRFIRRE 1290 KEIAETRFEV 1300 AQVESLRYRQ 1310 RVELLERELQ 1320 ELQDSLNVER 1330 EKVQVTAKTM 1340 AQHEELMKKT 1350 ETMNVVMETN 1360 KMLREEKERL 1370 EQNLQQMQAK 1380 VRKLELDILP 1390 LQEANAELSE 1400 KSGMLQAEKK 1410 LLEEDVKRWK 1420 ARNQQLINQQ 1430 KDPDTEEYRK 1440 LLSEKEIHTK 1450 RIQQLNEEVG 1460 RLKAEIARSN 1470 ASLTNNQNLI 1480 QSLREDLSKA 1490 RTEKEGIQKD 1500 LDAKIIDIQE 1510 KVKTITQVKK 1520 IGRRYKTQFE 1530 ELKAQQNKAM 1540 ETSTQSSGDH 1550 QEQHISVQEM 1560 QELKDTLSQS 1570 ETKTKSLEGQ 1580 VENLQKTLSE 1590 KETEARSLQE 1600 QTVQLQSELS 1610 RLRQDLQDKT 1620 TEEQLRQQMN 1630 EKTWKTLALA 1640 KSKITHLSGV 1650 KDQLTKEIEE 1660 LKQRNGALDQ 1670 QKDELDVRMT 1680 ALKSQYEGRI 1690 SRLERELREH 1700 QERHLEQRDE 1710 PQEPTNKAPE 1720 QQRQITLKTT 1730 PASGERGIAS 1740 TSDPPTANIK 1750 PTPVVSTPSK 1760 VTAAAMAGNK 1770 STPRASIRPM 1780 VTPATVTNPT 1790 TTPTATVMPT 1800 TQVESQEAMQ 1810 SEGPVEHVPV 1820 FGNASGSVRS 1830 TSPNVQPSIS 1840 QPILTVQQQT 1850 QATAFVQPTQ 1860 QSHPQIEPTN 1870 QELSPNIVEV 1880 VQSSPVERPS 1890 TSTAVFGTVS 1900 ATPSSSLPKR 1910 TREEEEDSTM 1920 EAGDQVSEDT 1930 VEMPLPKKLK 1940 MVTPVGTEEE 1950 VMAEESTDGE 1960 AETQAYNQDS 1970 QDSIGEGVTQ 1980 GDYTPMEDSE 1990 ETSQSLQIDL 2000 GPLQSDQQTT 2010 SSQDGQGKGD 2020 DVIVIDSDDE 2030 DDDEENDGEH 2040 EDYEEDEDDD 2050 DDEEDDTGMG 2060 DEGEDSNEGT 2070 GSADGNDGYE 2080 ADDAEGGDGT 2090 DPGTETEESM 2100 GGAESHQRAA 2110 DSQNSGEGNT 2120 SAAESSFSQE 2130 VAREQQPTSA 2140 SERQTPQAPQ 2150 SPRRPPHPLP 2160 PRLTIHAPPQ 2170 ELGPPVQRIQ 2180 MTRRQSVGRG 2190 LQLTPGIGGM 2200 QQHFFDDEDR 2210 TVPSTPTLVV 2220 PHRTDGFAEA 2230 IHSPQVAGVP 2240 RFRFGPPEDM 2250 PQTSSSHSDL 2260 GQLASQGGLG 2270 MYETPLFLAH 2280 EEESGGRSVP 2290 TTPLQVAAPV 2300 TVFTESTTSD 2310 ASEHASQSVP 2320 MVTTSTGTLS 2330 TTNETAAGDD 2340 GDEVFVEAES 2350 EGISSEAGLE 2360 IDSQQEEEPV 2370 QASDESDLPS 2380 TSQDPPSSSS 2390 VDTSSSQPKP 2400 FRRVRLQTTL 2410 RQGVRGRQFN 2420 RQRGISHAMG 2430 GRGGINRGNI N

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005868	cytoplasmic dynein complex
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0072686	mitotic spindle
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0042405	nuclear inclusion body
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0034399	nuclear periphery
Cellular Component	GO:0005643	nuclear pore
Cellular Component	GO:0044615	nuclear pore nuclear basket
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0070840	dynein complex binding
Molecular Function	GO:0031072	heat shock protein binding
Molecular Function	GO:0051019	mitogen-activated protein kinase binding
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0017056	structural constituent of nuclear pore
Molecular Function	GO:0015631	tubulin binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0034605	cellular response to heat
Biological Process	GO:0035457	cellular response to interferon-alpha
Biological Process	GO:0007094	mitotic spindle assembly checkpoint signaling
Biological Process	GO:0006406	mRNA export from nucleus
Biological Process	GO:0031990	mRNA export from nucleus in response to heat stress
Biological Process	GO:0046832	negative regulation of RNA export from nucleus
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0045947	negative regulation of translational initiation
Biological Process	GO:0006999	nuclear pore organization
Biological Process	GO:0006913	nucleocytoplasmic transport
Biological Process	GO:0031453	positive regulation of heterochromatin formation
Biological Process	GO:0090316	positive regulation of intracellular protein transport
Biological Process	GO:0046827	positive regulation of protein export from nucleus
Biological Process	GO:0042307	positive regulation of protein import into nucleus
Biological Process	GO:0006611	protein export from nucleus
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0010965	regulation of mitotic sister chromatid separation
Biological Process	GO:1901673	regulation of mitotic spindle assembly
Biological Process	GO:0032880	regulation of protein localization
Biological Process	GO:0070849	response to epidermal growth factor
Biological Process	GO:0006405	RNA export from nucleus
Biological Process	GO:0006404	RNA import into nucleus

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.