Search Results
Overview
| Uniprot ID | F7ELS2 |
|---|---|
| Protein Name | T-complex protein 1 subunit zeta |
| Gene Name | Cct6a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | AVKTLNPKAEVARAQ |
| 199 | EIMEMKHKSETDTSL |
| 251 | VNSGFFYKSAEEREK |
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance
Protein Sequence
10
MAAVKTLNPK
20
AEVARAQAAL
30
AVNISAARGL
40
QDVLRTNLGP
50
KGTMKMLVSG
60
AGDIKLTKDG
70
NVLLHEMQIQ
80
HPTASLIAKV
90
ATAQDDITGD
100
GTTSNVLIIG
110
ELLKQADLYI
120
SEGLHPRIIT
130
EGFEAAKEKA
140
LQFLEQVKVS
150
KEMDRETLID
160
VARTSLRTKV
170
HAELADVLTE
180
AVVDSILAIR
190
KKDEPIDLFM
200
VEIMEMKHKS
210
ETDTSLIRGL
220
VLDHGARHPD
230
MKKRVENAYI
240
LTCNVSLEYE
250
KTEVNSGFFY
260
KSAEEREKLV
270
KAERKFIEDR
280
VKKIVELKKK
290
VCGDSDKGFV
300
VINQKGIDPF
310
SLDALAKEGI
320
VALRRAKRRN
330
MERQGLNMNS
340
LYNKPGWPPV
350
QRLTLPLPPE
360
PWDERLTLAC
370
GGIALNSFDD
380
LNPDCLGHAG
390
LVYEYTLGEE
400
KFTFIEKCNN
410
PRSVTLLVKG
420
PNKHTLTQIK
430
DAIRDGLRAV
440
KNAIDDGCVV
450
PGAGAVEVAL
460
AEALIKYKPS
470
VKGRAQLGVQ
480
AFADALLIIP
490
KVLAQNSGFD
500
LQETLVKVQA
510
EHSESGQLVG
520
VDLNTGEPMV
530
AAEMGVWDNY
540
CVKKQLLHSC
550
TVIATNILLV
560
DEIMRAGMSS
LKG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0005832 | chaperonin-containing T-complex |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0002199 | zona pellucida receptor complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0140662 | ATP-dependent protein folding chaperone |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Molecular Function | GO:0071987 | WD40-repeat domain binding |
| Biological Process | GO:0007339 | binding of sperm to zona pellucida |
| Biological Process | GO:1904851 | positive regulation of establishment of protein localization to telomere |
| Biological Process | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.