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Overview

Uniprot IDF7F1Y3
Protein Namevesicle-fusing ATPase
Gene NameVps4a
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
229 FPHLFTGKRTPWRGI

Function

No function data available.

Protein Sequence

10 MAAERQPRDS 20 GWAALGRAPR 30 SPSDSAPTAS 40 GSPARAESRP 50 ARLLSSGPTT 60 SAPPGRTEAA 70 SSTAGCGADP 80 GYEMTTSTLQ 90 KAIDLVTKAT 100 EEDKAKNYEE 110 ALRLYQHAVE 120 YFLHAIKYEA 130 HSDKAKESIR 140 AKCMQYLDRA 150 EKLKDYLRNK 160 EKHGKKPVKE 170 NQSEGKGSDS 180 DSEGDNPEKK 190 KLQEQLMGAV 200 VMEKPNIRWN 210 DVAGLEGAKE 220 ALKEAVILPI 230 KFPHLFTGKR 240 TPWRGILLFG 250 PPGTGKSYLA 260 KAVATEANNS 270 TFFSVSSSDL 280 MSKWLGESEK 290 LVKNLFELAR 300 QHKPSIIFID 310 EVDSLCGSRN 320 ENESEAARRI 330 KTEFLVQMQG 340 VGNNNDGTLV 350 LGATNIPWVL 360 DSAIRRRFEK 370 RIYIPLPEEA 380 ARAQMFRLHL 390 GSTPHNLTDA 400 NIHELARKTE 410 GYSGADISII 420 VRDSLMQPVR 430 KVQSATHFKK 440 VCGPSRTNPS 450 VMIDDLLTPC 460 SPGDPGAIEM 470 TWMDVPGDKL 480 LEPVVCMSDM 490 LRSLATTRPT 500 VNADDLLKVK 510 KFSEDFGQES

Gene Ontology

Classification GO ID Description
Biological Process GO:0034058 endosomal vesicle fusion
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0090543 Flemming body
Cellular Component GO:0031902 late endosome membrane
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0000922 spindle pole
Cellular Component GO:0005774 vacuolar membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140545 ATP-dependent protein disaggregase activity
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0016197 endosomal transport
Biological Process GO:0032367 intracellular cholesterol transport
Biological Process GO:0061738 late endosomal microautophagy
Biological Process GO:0090148 membrane fission
Biological Process GO:0061952 midbody abscission
Biological Process GO:0044878 mitotic cytokinesis checkpoint signaling
Biological Process GO:0007080 mitotic metaphase chromosome alignment
Biological Process GO:0036258 multivesicular body assembly
Biological Process GO:0032466 negative regulation of cytokinesis
Biological Process GO:0006997 nucleus organization
Biological Process GO:1903543 positive regulation of exosomal secretion
Biological Process GO:1903774 positive regulation of viral budding via host ESCRT complex
Biological Process GO:0006622 protein targeting to lysosome
Biological Process GO:1903076 regulation of protein localization to plasma membrane
Biological Process GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Biological Process GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
Biological Process GO:0006900 vesicle budding from membrane
Biological Process GO:0072319 vesicle uncoating
Biological Process GO:0046761 viral budding from plasma membrane
Biological Process GO:0039702 viral budding via host ESCRT complex

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.