Search Results
Overview
| Uniprot ID | F7FG68 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase synoviolin |
| Gene Name | Syvn1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 605 | LRRRRLQKLESPVAH |
Function
No function data available.
Protein Sequence
10
MFRTAVMMAA
20
SLALTGAVVA
30
HAYYLKHQFY
40
PTVVYLTKSS
50
PSMAVLYIQA
60
FVLVFLLGKV
70
MGKVFFGQLR
80
AAEMEHLLER
90
SWYAVTETCL
100
AFTVFRDDFS
110
PRFVALFTLL
120
LFLKCFHWLA
130
EDRVDFMERS
140
PNISWLFHCR
150
IVSLMFLLGI
160
LDFLFVSHAY
170
HSILTRGASV
180
QLVFGFEYAI
190
LMTMVLTIFI
200
KYVLHSVDLQ
210
SENPWDNKAV
220
YMLYTELFTG
230
FIKVLLYMAF
240
MTIMIKVHTF
250
PLFAIRPMYL
260
AMRQFKKAVT
270
DAIMSRRAIR
280
NMNTLYPDAT
290
PEELQAMDNV
300
CIICREEMVT
310
GAKRLPCNHI
320
FHTSCLRSWF
330
QRQQTCPTCR
340
MDVLRASLPA
350
QSPPPPEPAD
360
QGAPPAPHPP
370
PLLPQPPNFP
380
QGLLPPFPPG
390
MFPLWPPMGP
400
FPPVPPPPSS
410
GEAAAPPSTS
420
AATSRPSGAA
430
TTTAAGTSTS
440
APASGSVPGP
450
EAGPAPGFPF
460
PPPWMGMPLP
470
PPFAFPPMPV
480
PPAGFAGLTP
490
EELRALEGHE
500
RQHLEARLQS
510
LRNIHTLLDA
520
AMLQINQYLT
530
VLASLGPPRP
540
ATSVNPTEET
550
ASTVVSATPS
560
TSVPSSEAPA
570
PSLGASPPIP
580
EAEKPPAPES
590
VSTAEELPED
600
GEPDAAELRR
610
RRLQKLESPV
AH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0036513 | Derlin-1 retrotranslocation complex |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0044322 | endoplasmic reticulum quality control compartment |
| Cellular Component | GO:0000836 | Hrd1p ubiquitin ligase complex |
| Cellular Component | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0005790 | smooth endoplasmic reticulum |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:1990381 | ubiquitin-specific protease binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0036503 | ERAD pathway |
| Biological Process | GO:0002327 | immature B cell differentiation |
| Biological Process | GO:0001701 | in utero embryonic development |
| Biological Process | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0030163 | protein catabolic process |
| Biological Process | GO:0070936 | protein K48-linked ubiquitination |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0030970 | retrograde protein transport, ER to cytosol |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.