Search Results
Overview
| Uniprot ID | F7FGW7 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial |
| Gene Name | Ndufs8 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 45 | TYKYVNMKAQELDVD |
| 54 | QELDVDMKSATDSAA |
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I
Protein Sequence
10
MFQMYRLSSS
20
VLPRALAQAM
30
RTGHLNGQSL
40
HSSAVAATYK
50
YVNMKAQELD
60
VDMKSATDSA
70
ARILMWTELF
80
RGLGMTLSYL
90
FREPATINYP
100
FEKGPLSPRF
110
RGEHALRRYP
120
SGEERCIACK
130
LCEAICPAQA
140
ITIEAEPRAD
150
GSRRTTRYDI
160
DMTKCIYCGF
170
CQEACPVDAI
180
VEGPNFEFST
190
ETHEELLYNK
200
EKLLNNGDKW
210
EAEIAANIQA
DYLYR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Molecular Function | GO:0016651 | oxidoreductase activity, acting on NAD(P)H |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0032981 | mitochondrial respiratory chain complex I assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.