Search Results
Overview
| Uniprot ID | F7FKI5 |
|---|---|
| Protein Name | Pyruvate dehydrogenase E1 component subunit alpha |
| Gene Name | Pdha1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 63 | LTREDGLKYYRMMQT |
Function
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Protein Sequence
10
MRKMLAAVSR
20
VLAGAAQKPA
30
SRVLVASRNF
40
ANDATFEIKK
50
CDLHRLEEGP
60
PVTTVLTRED
70
GLKYYRMMQT
80
VRRMELKADQ
90
LYKQKIIRGF
100
CHLCDGQEAC
110
CVGLEAGINP
120
TDHLITAYRA
130
HGFTFTRGLP
140
VRAILAELTG
150
RRGGCAKGKG
160
GSMHMYAKNF
170
YGGNGIVGAQ
180
VPLGAGIALA
190
CKYNGKDEVC
200
LTLYGDGAAN
210
QGQIFEAYNM
220
AALWKLPCIF
230
ICENNRYGMG
240
TSVERAAAST
250
DYYKRGDFIP
260
GLRVDGMDIL
270
CVREATKFAA
280
AYCRSGKGPI
290
LMELQTYRYH
300
GHSMSDPGVS
310
YRTREEIQEV
320
RSKSDPIMLL
330
KDRMVNSNLA
340
SVEELKEIDV
350
EVRKEIEDAA
360
QFATADPEPP
370
LEELGYHIYS
380
SDPPFEVRGA
390
NQWIKFKSVS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity |
| Biological Process | GO:0006006 | glucose metabolic process |
| Biological Process | GO:0006086 | pyruvate decarboxylation to acetyl-CoA |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.