Search Results

Overview

Uniprot ID	F8WFR8
Protein Name	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Gene Name	Paics
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
359	TAGNAARKNHLEGKA

Function

Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway

Protein Sequence

10 MESGPGKHWT 20 EEEVKALLSV 30 WAERNIRKQL 40 YGTLRNREIF 50 IYVAKRLRSL 60 GVYRDWKQCR 70 AKYKNLKYEY 80 RTVKHAHRSG 90 DSSRTMKFFH 100 VLDAILQSEP 110 TARLTEESDG 120 NIKCLVTLSS 130 SSAPEITEGN 140 RIPLEGAESH 150 THTVTSNDPG 160 AGRHQPENEV 170 TALVQIWHGE 180 RVRQTPEETT 190 RNKGTSEETA 200 QRPIQFGIDR 210 DWKQCHDATH 220 KTPNREQRVL 230 QKTNDSPWRK 240 RRFHDETDCI 250 LKSRTPGITK 260 RKHETMSTPL 270 KKMSPEIITN 280 WFPQSLIDLE 290 GSTGCFFHQD 300 PHLHQIAASF 310 SRAVCSSSSP 320 RIMATAEVLN 330 IGRKLYEGKT 340 KEVYELLDSP 350 GRVLLQSKDQ 360 ITAGNAARKN 370 HLEGKAAISN 380 KITSCIFQLL 390 QEAGIKTAFT 400 KKCGETAFIA 410 PQCEMIPIEW 420 VCRRIATGSF 430 LKRNPGVKEG 440 YRFYPPKVEM 450 FFKDDANNDP 460 QWSEEQLIAA 470 KFCFAGLVIG 480 QTEVDIMSHA 490 TQAIFEILEK 500 SWLPQNCTLV 510 DMKIEFGVDV 520 TTKEIVLADV 530 IDNDSWRLWP 540 SGDRSQQKDK 550 QSYRDLKEVT 560 PEGLQMVKKN 570 FEWVADRVEL 580 LLKSNSQCRV 590 VVLMGSTSDL 600 GHCEKIKKAC 610 GNFGIPCELR 620 VTSAHKGPDE 630 TLRIKAEYEG 640 DGIPTVFVAV 650 AGRSNGLGPV 660 MSGNTAYPVI 670 SCPPITADWG 680 AQDVWSSLRL 690 PSGIGCSTIL 700 SPEGSAQFAA 710 QIFGLNNHLV 720 WAKLRASKLN 730 TWISLKQADK KIRECNL

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004638	phosphoribosylaminoimidazole carboxylase activity
Molecular Function	GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Biological Process	GO:0006189	'de novo' IMP biosynthetic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.