Search Results
Overview
| Uniprot ID | G3V3E8 |
|---|---|
| Protein Name | NPC intracellular cholesterol transporter 2 |
| Gene Name | NPC2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 94 | IPEPDGCKSGINCPI |
Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport
Protein Sequence
10
MRFLAATFLL
20
LALSTAAQAE
30
PVQFKDCGSV
40
DGVIKEVNVS
50
PCPTQPCQLS
60
KGQSYSVNVT
70
FTSNIQSKSS
80
KAVVHGILMG
90
VPVPFPIPEP
100
DGCKSGINCP
110
IQKDKTYSYL
120
NKLPVKSEYP
130
SIKLVVEWQL
140
QDDKNQSLFC
150
WEIPVQIVSL
160
SGGERAWVEG
170
RKWRRNQTET
KSVP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Molecular Function | GO:0032934 | sterol binding |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0032367 | intracellular cholesterol transport |
Reference
PMID: N/A