Search Results
Overview
| Uniprot ID | G3V647 |
|---|---|
| Protein Name | Pyridoxal kinase |
| Gene Name | Pdxk |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 161 | AELLSGRKIHSQEEA |
| 209 | LGSQRMRKPDGSTVT |
Function
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively. PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions
Protein Sequence
10
MEGECRVLSI
20
QSHVVRGYVG
30
NRAAMFPLQV
40
LGFEVDAVNS
50
VQFSNHTGYA
60
HWKGQVLTSQ
70
ELHALYEGLK
80
ANSVNKYDYV
90
LTGYTRDKSF
100
LGMVVDIVQE
110
LKQQNSRLVY
120
VCDPVMGDKW
130
NGEGSMYVPQ
140
DLLPVYREKV
150
VPMADIITPN
160
QFEAELLSGR
170
KIHSQEEAFA
180
VMDVLHRMGP
190
DTVVITSSDL
200
PSPKGSDYLM
210
ALGSQRMRKP
220
DGSTVTQRIR
230
MEMRKVDAVF
240
VGTGDLFAAM
250
LLAWTHKHPD
260
NLKVACEKTV
270
SAMQHVLQRT
280
IRCAKAEAGE
290
GQKPSPAQLE
300
LRMVQSRKDI
310
EDPEIVVQAT
VL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008478 | pyridoxal kinase activity |
| Biological Process | GO:0009443 | pyridoxal 5'-phosphate salvage |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.