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Overview

Uniprot IDG3V662
Protein NameNuclear pore complex protein Nup153
Gene NameNup153
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1072 KEDASATKGGFTFGK
411 KNSTVDEKNISRQNR

Function

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)

Protein Sequence

10 MASGAGGIGG 20 GGGGGKIRTR 30 RCHQGPVKPY 40 QQGRPQHQGI 50 LSRVTESVKN 60 IVPGWLQRYF 70 NKSENACSCS 80 VNADEVPRWP 90 ENREDEREIY 100 VDENTNTDDG 110 RTTPEPTGSN 120 TEEPSTTSTA 130 SNYPDVLTRP 140 SLHRSHLNFS 150 VLESPALHCQ 160 PSTSSAFPIG 170 SSGFSLVKEI 180 KDSTSQHDDD 190 NISTTSGFSS 200 RASEKDIAVS 210 KNTSLPPLWS 220 PEAERSHSLS 230 QHTAISSKKP 240 AFNLSAFGTL 250 STSLGNSSIL 260 KTSQLGDSPF 270 YPGKTTYGGA 280 AAAVRQNKVR 290 STPYQAPVRR 300 QMKAKQLNAQ 310 SYGVTSSTAR 320 RILQSLEKMS 330 SPLADAKRIP 340 SAVSSPLNSP 350 LDRSGIDSTV 360 FQAKKEKVDS 370 QYPPVQRLMT 380 PKPVSIATNR 390 TVYFKPSLTP 400 SGDLRKTNQR 410 IDKKNSTVDE 420 KNISRQNREQ 430 ESGFSYPNFS 440 IPAANGLSSG 450 VGGGGGKMRR 460 ERTTHFVASK 470 PSEEEEVEVP 480 LLPQISLPIS 490 SSSLPTFNFS 500 SPAISAASSS 510 SVSPSQPLSN 520 KVQMTSLGST 530 GNPVFTFSSP 540 IVKSTQADVL 550 PPASIGFTFS 560 VPLAKTELSG 570 PNSSSETVLS 580 SSVTAQDNTV 590 VNSSSSKKRS 600 APCEDPFTPA 610 KILREGSVLD 620 ILKTPGFMSP 630 KVDSPALQPT 640 TTSSIVYTRP 650 AISTFSSSGV 660 EFGESLKAGS 670 SWQCDTCLLQ 680 NKVTDNKCIA 690 CQAAKLPLKE 700 TAKQTGIGTP 710 SKSDKPASTS 720 GTGFGDKFKP 730 AIGTWDCDTC 740 LVQNKPEAVK 750 CVACETPKPG 760 TGVKRALPLT 770 VASESPVTAS 780 SSTTVTTGTL 790 GFGDKFKRPV 800 GSWECPVCCV 810 SNKAEDSRCV 820 SCTSEKPGLV 830 SASSSNPVPV 840 SLPSGGCLGL 850 DKFKKPEGSW 860 DCEVCLVQNK 870 ADSTKCIACE 880 SAKPGTKSEF 890 KGFGTSSSLN 900 PAPSAFKFGI 910 PSSSSGLSQT 920 FTSTGNFKFG 930 DQGGFKLGTS 940 SDSGSTNTMN 950 TNFKFPKPTG 960 DFKFGVLPDS 970 KPEEIKNDSK 980 NDNFQFGPSS 990 GLSNPASSAP 1000 FQFGVSTLGQ 1010 QEKKEELPQS 1020 SSAGFSFGAG 1030 VANPSSAAID 1040 TTVTSENKSG 1050 FNFGTIDTKS 1060 VSVTPFTYKT 1070 TEAKKEDASA 1080 TKGGFTFGKV 1090 DSAALSSPSM 1100 FVLGRTEEKQ 1110 QEPVTSTSLV 1120 FGKKADNEEP 1130 KCQPVFSFGN 1140 SEQTKDESSS 1150 KPTFSFSVAK 1160 PSVKESDQLA 1170 KATFAFGNQT 1180 NTTTDQGAAK 1190 PAFSFLNSSS 1200 SSSSTPATSS 1210 SASIFGSSTS 1220 SSSPPVAAFV 1230 FGQASNPVSS 1240 SAFGNSAESS 1250 TSQPLLFPQD 1260 GKPATTSSTA 1270 SAAPPFVFGT 1280 GASSNSTVSS 1290 GFTFGATTTS 1300 SSSGSFFVFG 1310 TGHSAPSASP 1320 AFGANQTPTF 1330 GQSQGASQPN 1340 PPSFGSISSS 1350 TALFSAGSQP 1360 VPPPTFGTVS 1370 SSSQPPVFGQ 1380 QPSQSAFGSG 1390 TANASSVFQF 1400 GSSTTNFNFT 1410 NNNPSGVFTF 1420 GASPSTPAAA 1430 AQPSGSGGFS 1440 FSQSPASFTV 1450 GSNGKNMFSS 1460 SGTSVSGRKI KTAVRRKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042405 nuclear inclusion body
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0034399 nuclear periphery
Cellular Component GO:0044615 nuclear pore nuclear basket
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0140693 molecular condensate scaffold activity
Molecular Function GO:0043495 protein-membrane adaptor activity
Molecular Function GO:0017056 structural constituent of nuclear pore
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:1990000 amyloid fibril formation
Biological Process GO:0051028 mRNA transport
Biological Process GO:0046832 negative regulation of RNA export from nucleus
Biological Process GO:0051292 nuclear pore complex assembly
Biological Process GO:0015031 protein transport

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.