Search Results
Overview
| Uniprot ID | G3V6C4 |
|---|---|
| Protein Name | UDP-glucose 6-dehydrogenase |
| Gene Name | Ugdh |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 129 | GYKIVTEKSTVPVRA |
| 329 | LFNTVTDKKIAILGF |
| 480 | YTPGEIPKFSLQDPP |
| 489 | SLQDPPNKKPKV*** |
Function
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans. Required for proper brain and neuronal development
Protein Sequence
10
MVEIKKICCI
20
GAGYVGGPTC
30
SVIAHMCPEI
40
RVTVVDVNEA
50
RINAWNSPTL
60
PIYEPGLKEV
70
VESCRGKNLF
80
FSTNIDDAIR
90
EADLVFISVN
100
TPTKTYGMGK
110
GRAADLKYIE
120
ACARRIVQNS
130
NGYKIVTEKS
140
TVPVRAAESI
150
RRIFDANTKP
160
NLNLQVLSNP
170
EFLAEGTAIK
180
DLKNPDRVLI
190
GGDETPEGQR
200
AVQALCAVYE
210
HWVPKEKILT
220
TNTWSSELSK
230
LAANAFLAQR
240
ISSINSISAL
250
CEATGADVEE
260
VATAIGMDQR
270
IGNKFLKASV
280
GFGGSCFQKD
290
VLNLVYLCEA
300
LNLPEVARYW
310
QQVIDMNDYQ
320
RRRFASRIID
330
SLFNTVTDKK
340
IAILGFAFKK
350
DTGDTRESSS
360
IYISKYLMDE
370
GAHLHIYDPK
380
VPREQIVVDL
390
SHPGVSADDQ
400
VSRLVTISKD
410
PYEACDGAHA
420
LVICTEWDMF
430
KELDYERIHK
440
RMLKPAFIFD
450
GRRVLDGLHN
460
ELQTIGFQIE
470
TIGKKVSSKR
480
IPYTPGEIPK
490
FSLQDPPNKK
PKV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0003979 | UDP-glucose 6-dehydrogenase activity |
| Biological Process | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process |
| Biological Process | GO:0006024 | glycosaminoglycan biosynthetic process |
| Biological Process | GO:0015012 | heparan sulfate proteoglycan biosynthetic process |
| Biological Process | GO:0048666 | neuron development |
| Biological Process | GO:0034214 | protein hexamerization |
| Biological Process | GO:0006065 | UDP-glucuronate biosynthetic process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.