Search Results

Overview

Uniprot ID	G3V6D3
Protein Name	ATP synthase subunit beta
Gene Name	Atp5f1b
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
124	EGLVRGQKVLDSGAP
133	LDSGAPIKIPVGPET
198	DLLAPYAKGGKIGLF
201	APYAKGGKIGLFGGA
259	ESGVINLKDATSKVA

Function

Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain

Protein Sequence

10 MLSLVGRVAS 20 ASASGALRGL 30 NPLAALPQAQ 40 LLLRTAPAGV 50 HPARDYAAQS 60 SAAPKAGTAT 70 GQIVAVIGAV 80 VDVQFDEGLP 90 PILNALEVQG 100 RESRLVLEVA 110 QHLGESTVRT 120 IAMDGTEGLV 130 RGQKVLDSGA 140 PIKIPVGPET 150 LGRIMNVIGE 160 PIDERGPIKT 170 KQFAPIHAEA 180 PEFIEMSVEQ 190 EILVTGIKVV 200 DLLAPYAKGG 210 KIGLFGGAGV 220 GKTVLIMELI 230 NNVAKAHGGY 240 SVFAGVGERT 250 REGNDLYHEM 260 IESGVINLKD 270 ATSKVALVYG 280 QMNEPPGARA 290 RVALTGLTVA 300 EYFRDQEGQD 310 VLLFIDNIFR 320 FTQAGSEVSA 330 LLGRIPSAVG 340 YQPTLATDMG 350 TMQERITTTK 360 KGSITSVQLF 370 RLPSTHARWL 380 IIYNFSSRKS 390 GALFQPPQVP 400 AHTAIYVPAD 410 DLTDPAPATT 420 FAHLDATTVL 430 SRAIAELGIY 440 PAVDPLDSTS 450 RIMDPNIVGS 460 EHYDVARGVQ 470 KILQDYKSLQ 480 DIIAILGMDE 490 LSEEDKLTVS 500 RARKIQRFLS 510 QPFQVAEVFT 520 GHMGKLVPLK 530 ETIKGFQQIL 540 AGDYDHLPEQ 550 AFYMVGPIEE 560 AVAKADKLAE EHGS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0031966	mitochondrial membrane
Cellular Component	GO:0042645	mitochondrial nucleoid
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0045259	proton-transporting ATP synthase complex
Molecular Function	GO:0043532	angiostatin binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0042288	MHC class I protein binding
Molecular Function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
Molecular Function	GO:0046961	proton-transporting ATPase activity, rotational mechanism
Biological Process	GO:0001525	angiogenesis
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration
Biological Process	GO:0042776	proton motive force-driven mitochondrial ATP synthesis
Biological Process	GO:0051453	regulation of intracellular pH

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.