Search Results

Overview

Uniprot ID	G3V6F5
Protein Name	Zinc phosphodiesterase ELAC protein 2
Gene Name	Elac2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
28	ARRPRPPKDPLRHLR

Function

Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly

Protein Sequence

10 MWALRSLLRP 20 LGLRTMSQGS 30 ARRPRPPKDP 40 LRHLRTREKR 50 GPGWGPGGPN 60 TVYLQVVAAG 70 GRDAGAALYV 80 FSEYNRYLFN 90 CGEGVQRLMQ 100 EHKLKVARLD 110 NIFLTRMHWS 120 NVGGLCGMIL 130 TLKETGLPKC 140 VLSGPPQLEK 150 YLEAIKIFSG 160 PLKGIDLAVR 170 PHSAPEYKDE 180 TMTVYQVPIH 190 SERRCGEQEP 200 SRSPKRSPNR 210 LSPKQSSSDP 220 GSAENGQCLP 230 EGSSAGVNGK 240 AWGRDPSLVV 250 AFVCKLHLRK 260 GNFLVLKAKE 270 LGLPVGTAAI 280 APIIAAVKDG 290 KSITYEGREI 300 AAEELCTPPD 310 PGLVFIVVEC 320 PDEGFIQPIC 330 ENDTFQRYQG 340 EADAPVAVVV 350 HIAPESVLID 360 SRYQQWMERF 370 GPDTQHLILN 380 ENCPSVHNLR 390 SHKIQTQLSL 400 IHPDIFPQLT 410 SFHSKEEGST 420 FSLPTVRGEC 430 LLKYQLRPKR 440 EWQRDTTLDC 450 NTDEFIAEAL 460 ELPNFQESVE 470 EYRKNMQASP 480 APAEKRSQYP 490 EIVFLGTGSA 500 IPMKIRNVSS 510 TLVNLSPDKS 520 VLLDCGEGTF 530 GQLCRHYGQQ 540 IDRVLCNLTA 550 VFVSHLHADH 560 HTGLLNILLQ 570 REHALASLGK 580 PFQPLLVVAP 590 TQLRAWLQQY 600 HNQCQEILHH 610 ISMIPAKCLQ 620 KGAEVPSPPV 630 ERLISLLLET 640 CDLQEFQTCL 650 VRHCKHAFGC 660 ALVHSSGWKV 670 VYSGDTMPCE 680 ALVQMGKDAT 690 LLIHEATLED 700 GLEEEAVEKT 710 HSTTSQAIGV 720 GMRMNAEFIM 730 LNHFSQRYAK 740 IPLFSPDFNE 750 KVGIAFDHMK 760 VCFGDFPTVP 770 KLIPPLKALF 780 ADDIEEMVER 790 REKRELRLVR 800 AALLTQQADS 810 SEDREPHQKR 820 AHSEEPHSPQ SKKVRAQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0042645	mitochondrial nucleoid
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0042781	3'-tRNA processing endoribonuclease activity
Molecular Function	GO:0046872	metal ion binding

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.