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Overview

Uniprot ID	G3V6H5
Protein Name	Mitochondrial 2-oxoglutarate/malate carrier protein
Gene Name	Slc25a11
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
256	NMRMIDGKPEYKNGL
57	QLSGEGAKTREYKTS
62	GAKTREYKTSFHALT
73	HALTSILKAEGLRGI

Function

Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. Does not transport glutathione. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis

Protein Sequence

10 MAATASPGAG 20 RMDGKPRTSP 30 KSVKFLFGGL 40 AGMGATVFVQ 50 PLDLVKNRMQ 60 LSGEGAKTRE 70 YKTSFHALTS 80 ILKAEGLRGI 90 YTGLSAGLLR 100 QATYTTTRLG 110 IYTVLFERLT 120 GADGTPPGFL 130 LKALIGMTAG 140 ATGAFVGTPA 150 EVALIRMTAD 160 GRLPADQRRG 170 YKNVFNALIR 180 IAREEGVPTL 190 WRGCIPTMAR 200 AVVVNAAQLA 210 SYSQSKQFLL 220 DSGYFSDNIL 230 CHFCASMISG 240 LVTTAASMPV 250 DIVKTRIQNM 260 RMIDGKPEYK 270 NGLDVLLKVV 280 RYEGFFSLWK 290 GFTPYYARLG 300 PHTVLTFIFL 310 EQMNKAYKRL FLGG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Molecular Function	GO:0015367	oxoglutarate:malate antiporter activity
Biological Process	GO:0006094	gluconeogenesis
Biological Process	GO:0006869	lipid transport
Biological Process	GO:0043490	malate-aspartate shuttle

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.