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Overview

Uniprot ID	G3V6L8
Protein Name	Striatin
Gene Name	Strn
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
353	VKRPNRSKLQDMLAN
500	QKTAPAKKSTSLDVE

Function

Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation

Protein Sequence

10 MDEQAGPGVF 20 FSNNHPGAGG 30 AKGLGPLAEA 40 AAAGDGAAAA 50 GAARAQYSLP 60 GILHFLQHEW 70 ARFEVERAQW 80 EVERAELQAQ 90 IAFLQGERKG 100 QENLKKDLVR 110 RIKMLEYALK 120 QERAKYHKLK 130 YGTELNQGDM 140 KPPSYDSDEG 150 NETEVQPQQN 160 SQFMWKQGRQ 170 LLRQYLQEVG 180 YTDTILDVKS 190 KRVRALLGFS 200 SDVTDREDDK 210 NQDSVINGTE 220 AEVKETAMIG 230 KSELTDSASV 240 LDNFKFLENA 250 AADFSDEDED 260 EDIDGREKSV 270 IDTSTIVRKK 280 PLPDTSEDRD 290 TKEALKEFDF 300 LVASEEGDNE 310 SRSAGDGTDW 320 EKEDQCLTPE 330 AWNVDQGVIT 340 RLKEQYKKER 350 KGKKGVKRPN 360 RSKLQDMLAN 370 LRDVDELPSL 380 QPSVGSPSRP 390 SSSRLPEQDI 400 SRADEVEALT 410 FPPSSGKSFI 420 MGADEALESE 430 LGLGELAGLT 440 VANEADSLAY 450 DIANNKDALR 460 KTWNPKFTLR 470 SHFDGIRALA 480 FHPIEPVLIT 490 ASEDHTLKMW 500 NLQKTAPAKK 510 STSLDVEPIY 520 TFRAHKGPVL 530 CVVMSSNGEQ 540 CYSGGTDGLI 550 QSWSTTNPNV 560 DPYDSYDPSV 570 LRGPLLGHTD 580 AVWGLAYSAA 590 HQRLLSCSAD 600 GTLRLWTTTE 610 VAPALTVFND 620 NQELGIPASV 630 DLVSSDPSHM 640 VASFSKGYTS 650 IFNMETQQRI 660 LTLESNVDST 670 ASSSCQINRV 680 ISHPTLPISI 690 TAHEDRHIKF 700 YDNNTGKLIH 710 SMVAHLEAVT 720 SLAVDPNGLY 730 LMSGSHDCSI 740 RLWNLESKTC 750 IQEFTAHRKK 760 FEESIHDVAF 770 HPSKCYIASA 780 GADALAKVFV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0032991	protein-containing complex
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0044877	protein-containing complex binding

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.