Search Results
Overview
| Uniprot ID | G3V6M3 |
|---|---|
| Protein Name | Synaptotagmin |
| Gene Name | Syt2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 237 | YDFDRFSKHDIIGEV |
Function
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone
Protein Sequence
10
MRNIFKRNQE
20
PIVAPATTTA
30
TMPLAPAAPV
40
DNSTESTGTG
50
ESQEDMFAKL
60
KDKFFNEINK
70
IPLPPWALIA
80
MAVVAGLLLL
90
TCCFCICKKC
100
CCKKKKNKKE
110
KGKGMKNAMN
120
MKDMKGGQDD
130
DDAETGLTEG
140
EGEGEEEKEP
150
ENLGKLQFSL
160
DYDFQANQLT
170
VGVLQAAELP
180
ALDMGGTSDP
190
YVKVFLLPDK
200
KKKYETKVHR
210
KTLNPAFNET
220
FTFKVPYQEL
230
GGKTLVMAIY
240
DFDRFSKHDI
250
IGEVKVPMNT
260
VDLGQPIEEW
270
RDLQGGEKEE
280
PEKLGDICTS
290
LRYVPTAGKL
300
TVCILEAKNL
310
KKMDVGGLSD
320
PYVKIHLMQN
330
GKRLKKKKTT
340
VKKKTLNPYF
350
NESFSFEIPF
360
EQIQKVQVVV
370
TVLDYDKLGK
380
NEAIGKIFVG
390
SNATGTELRH
400
WSDMLANPRR
410
PIAQWHSLKP
420
EEEVDALLGK
NK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042584 | chromaffin granule membrane |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:1903861 | positive regulation of dendrite extension |
| Biological Process | GO:0045055 | regulated exocytosis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.