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Overview

Uniprot IDG3V6P2
Protein NameDihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Gene NameDlst
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
155 GAAPAKAKPAEAPAT
204 SKPVSAIKPTAAPPL
218 LAEAGAAKGLRSEHR
268 QEMRARHKDAFLKKH
354 TINELGEKARKNELA

Function

Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A

Protein Sequence

10 MLSRSRCVSR 20 AFSRSLSAFQ 30 KGNCPLGRRS 40 LPGVSLCQGP 50 GYPDSRKMVI 60 NNSSVFSVRF 70 FQTTAVCKND 80 VITVQTPAFA 90 ESVTEGDVRW 100 EKAVGDAVAE 110 DEVVCEIETD 120 KTSVQVPSPA 130 NGIIEALLVP 140 DGGKVEGGTP 150 LFTLRKTGAA 160 PAKAKPAEAP 170 ATAHKAAPEA 180 PAAPPPPVAP 190 VPTQMPPVPS 200 PSQPPSSKPV 210 SAIKPTAAPP 220 LAEAGAAKGL 230 RSEHREKMNR 240 MRQRIAQRLK 250 EAQNTCAMLT 260 TFNEVDMSNI 270 QEMRARHKDA 280 FLKKHNLKLG 290 FMSAFVKASA 300 FALQEQPVVN 310 AVIDDATKEV 320 VYRDYIDISV 330 AVATPRGLVV 340 PVIRNVETMN 350 YADIERTINE 360 LGEKARKNEL 370 AIEDMDGGTF 380 TISNGGVFGS 390 LFGTPIINPP 400 QSAILGMHGI 410 FDRPVAVGGK 420 VEVRPMMYVA 430 LTYDHRLIDG 440 REAVTFLRKI 450 KAAVEDPRVL LLDL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005634 nucleus
Cellular Component GO:0045252 oxoglutarate dehydrogenase complex
Molecular Function GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity
Biological Process GO:0033512 L-lysine catabolic process to acetyl-CoA via L-saccharopine
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.