Search Results
Overview
| Uniprot ID | G3V6P7 |
|---|---|
| Protein Name | Myosin-9 |
| Gene Name | Myh9 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1014 | NLMEEEEKSKSLAKL |
| 1024 | SLAKLKNKHEAMITD |
| 1048 | KQRQELEKTRRKLEG |
| 1081 | LKMQLAKKEEELQAA |
| 1099 | VEEEAAQKNMALKKI |
| 1173 | EQEVSILKKTLEDEA |
| 1174 | QEVSILKKTLEDEAK |
| 1181 | KTLEDEAKTHEAQIQ |
| 1209 | AEQLEQTKRVKATLE |
| 1212 | LEQTKRVKATLEKAK |
| 1219 | KATLEKAKQTLENER |
| 1234 | GELANEVKALLQGKG |
| 1240 | VKALLQGKGDSEHKR |
| 1249 | DSEHKRKKVEAQLQE |
| 1274 | VRTELADKVSKLQVR |
| 1277 | ELADKVSKLQVRLLL |
| 1338 | EAKRNLEKQIATLHA |
| 1352 | AQVTDMKKKMEDGVG |
| 1391 | EKVAAYDKLEKTKTR |
| 1426 | NLEKKQKKFDQLLAE |
| 180 | TGESGAGKTENTKKV |
| 186 | GKTENTKKVIQYLAH |
| 1918 | VTRRIVRKGTGDCSD |
| 199 | AHVASSHKSKKDQGE |
| 202 | ASSHKSKKDQGELER |
| 29 | AQADWAAKKLVWVPS |
| 299 | LLLEPYNKYRFLSNG |
| 30 | QADWAAKKLVWVPST |
| 355 | QLGNIVFKKERNTDQ |
| 403 | VGRDYVQKAQTKEQA |
| 435 | WLVLRINKALDKTKR |
| 540 | WFPKATDKSFVEKVV |
| 545 | TDKSFVEKVVQEQGT |
| 555 | QEQGTHPKFQKPKQL |
| 560 | HPKFQKPKQLKDKAD |
| 565 | KPKQLKDKADFCIIH |
| 576 | CIIHYAGKVDYKADE |
| 580 | YAGKVDYKADEWLMK |
| 613 | KFVSELWKDVDRIIG |
| 651 | RTVGQLYKEQLAKLM |
| 656 | LYKEQLAKLMATLRN |
| 682 | NHEKKAGKLDPHLVL |
| 69 | GKKVKVNKDDIQKMN |
| 737 | PKGFMDGKQACVLMI |
| 74 | VNKDDIQKMNPPKFS |
| 760 | LYRIGQSKVFFRAGV |
| 8 | MAQQAADKYLYVDKN |
| 835 | WRLFTKVKPLLNSIR |
| 850 | HEDELLAKEAELTKV |
| 860 | ELTKVREKHLAAENR |
| 910 | RARLTAKKQELEEIC |
| 938 | CQYLQAEKKKMQQNI |
| 961 | EEESARQKLQLEKVT |
| 966 | RQKLQLEKVTTEAKL |
| 972 | EKVTTEAKLKKLEED |
| 975 | TTEAKLKKLEEDQII |
| 989 | IMEDQNCKLAKEKKL |
Function
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis. Promotes cell motility in conjunction with S100A4. During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0060473 | cortical granule |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016459 | myosin complex |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0003774 | cytoskeletal motor activity |
| Biological Process | GO:0051017 | actin filament bundle assembly |
| Biological Process | GO:0070650 | actin filament bundle distribution |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0032970 | regulation of actin filament-based process |
| Biological Process | GO:0008360 | regulation of cell shape |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.