Search Results
Overview
| Uniprot ID | G3V6S8 |
|---|---|
| Protein Name | Serine/arginine-rich splicing factor 6 |
| Gene Name | Srsf6 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | RRTSGRDKYGPPVRT |
Function
Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity)
Protein Sequence
10
MPRVYIGRLS
20
YNVREKDIQR
30
FFSGYGRLLE
40
IDLKNGYGFV
50
EFEDSRDADD
60
AVYELNSKEL
70
CGERVIVEHA
80
RGPRRDRDGY
90
SYGSRSGGGG
100
YSSRRTSGRD
110
KYGPPVRTEY
120
RLIVENLSSR
130
CSWQDLKDFM
140
RQAGEVTYAD
150
AHKERTNEGV
160
IEFRSYSDMK
170
RALDKLDGTE
180
INGRNIRLIE
190
DKPRTSHRRS
200
YSGSRSRSRS
210
RRRSRSRSRR
220
SSRSRSRSIS
230
KSRSRSRSRS
240
KGRSRSRSKG
250
RKSRSKSKSK
260
PKSDRGSHSH
270
SRSRSKDKYG
280
KSRSRSRSRS
290
PKENGKGDIK
300
SKSRSRSQSR
310
SHSPLPAPPS
320
KARSMSPPPK
330
RASRSRSRSR
SRSRSSSRD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0036002 | pre-mRNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0000380 | alternative mRNA splicing, via spliceosome |
| Biological Process | GO:0006376 | mRNA splice site recognition |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0045617 | negative regulation of keratinocyte differentiation |
| Biological Process | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process |
| Biological Process | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis |
| Biological Process | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| Biological Process | GO:0010837 | regulation of keratinocyte proliferation |
| Biological Process | GO:0061041 | regulation of wound healing |
| Biological Process | GO:0032868 | response to insulin |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.