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Overview

Uniprot IDG3V6T1
Protein NameCoatomer subunit alpha
Gene NameCopa
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1075 CMEIERKKLPKETLD

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors

Protein Sequence

10 LLSSADTRHA 20 YVTKENSLSF 30 HPKRPWILTS 40 LHNGVIQLWD 50 YRMCTLIDKF 60 DEHDGPVRGI 70 DFHKQQPLFV 80 SGGDDYKIKV 90 WNYKLRRCLF 100 TLLGHLDYIR 110 TTFFHHEYPW 120 ILSASDDQTI 130 RVWNWQSRTC 140 VCVLTGHNHY 150 VMCAQFHPSE 160 DLVVSASLDQ 170 TVRVWDISGL 180 RKKNLSPGAV 190 ESDVRGITGV 200 DLFGTTDAVV 210 KHVLEGHDRG 220 VNWAAFHPTM 230 PLIVSGADDR 240 QVKIWRMNES 250 KAWEVDTCRG 260 HYNNVSCAVF 270 HPRQELILSN 280 SEDKSIRVWD 290 MSKRTGVQTF 300 RRDHDRFWVL 310 AAHPNLNLFA 320 AGHDGGMIVF 330 KLERERPAYA 340 VHGNMLHYVK 350 DRFLRQLDFN 360 SSKDVAVMQL 370 RSGSKFPVFN 380 MSYNPAENAV 390 LLCTRASNLE 400 NSTYDLYTIP 410 KDADSQNPDA 420 PEGKRSSGLT 430 AVWVARNRFA 440 VLDRMHSLLI 450 KNLKNEITKK 460 IQVPNCDEIF 470 YAGTGNLLLR 480 DADSITLFDV 490 QQKRTLASVK 500 ISKVKYVIWS 510 ADMSHVALLA 520 KHAIVICNRK 530 LDALCNIHEN 540 IRVKSGAWDE 550 SGVFIYTTSN 560 HIKYAVTTGD 570 HGIIRTLDLP 580 IYVTRVKGNN 590 VYCLDRECRP 600 RVLTIDPTEF 610 KFKLALINRK 620 YDEVLHMVRN 630 AKLVGQSIIA 640 YLQKKGYPEV 650 ALHFVKDEKT 660 RFSLALECGN 670 IEIALEAAKA 680 LDDKNCWEKL 690 GEVALLQGNH 700 QIVEMCYQRT 710 KNFDKLSFLY 720 LITGNLEKLR 730 KMMKIAEIRK 740 DMSGHYQNAL 750 YLGDVSERVR 760 ILKNCGQKSL 770 AYLTAATHGL 780 DEEAESLKET 790 FDPEKETIPD 800 IDPNAKLLQP 810 PAPIMPLDTN 820 WPLLTVSKGF 830 FEGSIASKGK 840 GGALAADIDI 850 DTVGTEGWGE 860 DAELQLDEDG 870 FVEAPEGLGE 880 DTLGKGQEEG 890 GGWDVEEDLE 900 LPPELDVPSG 910 VAGGAEDGFF 920 VPPTKGTSPT 930 QIWCNNSQLP 940 VDHILAGSFE 950 TAMRLLHDQV 960 GVVQFGPYKQ 970 LFLQTYARGR 980 TTYQALPCLP 990 SMYSYPNRNW 1000 KDAGLKNGVP 1010 AVGLKLNDLI 1020 QRLQLCYQLS 1030 TVGKFEDAVE 1040 KFRSILLSVP 1050 LLVVDNKQEI 1060 AEAQQLITIC 1070 REYIVGLCME 1080 IERKKLPKET 1090 LDQQKRICEM 1100 AAYFTHSNLQ 1110 PVHMILVLRT 1120 ALNLFFKLKN 1130 FKTAATFARR 1140 LLELGPKPEV 1150 AQQTRKILSA 1160 CEKNPTDACQ 1170 LNYDMHNPFD 1180 ICAASYRPIY 1190 RGKPVEKCPL 1200 SGACYSPEFK 1210 GQICRVTTVT 1220 EIGKDVIGLR ISPLQFR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030126 COPI vesicle coat
Cellular Component GO:0030137 COPI-coated vesicle
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0030426 growth cone
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0030157 pancreatic juice secretion
Biological Process GO:0099612 protein localization to axon
Biological Process GO:1902463 protein localization to cell leading edge

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.