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Overview

Uniprot ID	G3V6Y6
Protein Name	Alpha-1,4 glucan phosphorylase
Gene Name	Pygb
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
3	*****MAKPLTDSER

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Protein Sequence

10 MAKPLTDSER 20 QKQISVRGIA 30 GLGDVAEVRK 40 SFNRHLHFTL 50 VKDRNVATPR 60 DYFFALAHTV 70 RDHLVGRWIR 80 TQQHYYERDP 90 KRIYYLSLEF 100 YMGRTLQNTM 110 VNLGLQTACD 120 EATYQLGLDL 130 EELEEIEEDA 140 GLGNGGLGRL 150 AACFLDSMAT 160 LGLAAYGYGI 170 RYEFGIFNQK 180 IVNGWQVEEA 190 DDWLRYGNPW 200 EKARPEYMLP 210 VHFYGRVEHT 220 PNGVLWLDTQ 230 VVLAMPYDTP 240 VPGYKNNTVN 250 TMRLWSAKAP 260 NDFKLKDFNV 270 GDYIEAVLDR 280 NLAENISRVL 290 YPNDNFFEGK 300 ELRLKQEYFV 310 VAATLQDIIR 320 RFKSSKFGCR 330 DPVRTCFETF 340 PDKVAIQLND 350 THPALSIPEL 360 MRILVDVEKV 370 DWDKAWEITK 380 KTCAYTNHTV 390 LPEALERWPV 400 SMFEKLLPRH 410 LEIIYAINQR 420 HLDHVAALFP 430 GDVDRLRRMS 440 VIEEGDCKRI 450 NMAHLCVIGS 460 HAVNGVARIH 470 SEIVKQSVFK 480 DFYELEPEKF 490 QNKTNGITPR 500 RWLLLCNPGL 510 AEIIVERIGE 520 GFLTDLSQLK 530 KLLSLVDDEA 540 FIRDVAKVKQ 550 ENKLKFSAQL 560 EKEYKVKINP 570 ASMFDVHVKR 580 IHEYKRQLLN 590 CLHIITLYNR 600 IKKDPTKTFV 610 PRTVMIGGKA 620 APGYHMAKMI 630 IKLVTSIGDV 640 VNHDPVVGDR 650 LRVIFLENYR 660 VSLAEKVIPA 670 ADLSQQISTA 680 GTEASGTGNM 690 KFMLNGALTI 700 GTMDGANVEM 710 AEEAGEENLF 720 IFGMRVEDVE 730 ALDQKGYNAR 740 EFYERLPELR 750 QAVDQISSGF 760 FSPKDPDCFK 770 DVVNMLMYHD 780 RFKVFADYEA 790 YIQCQAQVDH 800 LYRNPKDWTK 810 KTEQRSALDP 820 DVGPIGHQAP 830 GKMQTHVTGS 840 RLHDTVGRAC FPTLPA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0030246	carbohydrate binding
Molecular Function	GO:0008184	glycogen phosphorylase activity
Molecular Function	GO:0030170	pyridoxal phosphate binding
Biological Process	GO:0005980	glycogen catabolic process

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.