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Overview

Uniprot IDG3V6Z5
Protein NameGlutamate receptor
Gene NameGria3
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
787 SEQGILDKLKNKWWY

Function

Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system

Protein Sequence

10 MGQSVLRAVF 20 FLVLGLLGHS 30 HGGFPNTISI 40 GGLFMRNTVQ 50 EHSAFRFAVQ 60 LYNTNQNTTE 70 KPFHLNYHVD 80 HLDSSNSFSV 90 TNAFCSQFSR 100 GVYAIFGFYD 110 QMSMNTLTSF 120 CGALHTSFVT 130 PSFPTDADVQ 140 FVIQMRPALK 150 GAILSLLGYY 160 KWEKFVYLYD 170 TERGFSVLQA 180 IMEAAVQNNW 190 QVTARSVGNI 200 KDVQEFRRII 210 EEMDRRQEKR 220 YLIDCEVERI 230 NTILEQVVIL 240 GKHSRGYHYM 250 LANLGFTDIL 260 LERVMHGGAN 270 ITGFQIVNNE 280 NPMVQQFIQR 290 WVRLDEREFP 300 EAKNAPLKYT 310 SALTHDAILV 320 IAEAFRYLRR 330 QRVDVSRRGS 340 AGDCLANPAV 350 PWSQGIDIER 360 ALKMVQVQGM 370 TGNIQFDTYG 380 RRTNYTIDVY 390 EMKVSGSRKA 400 GYWNEYERFV 410 PFSDQQISND 420 SSSSENRTIV 430 VTTILESPYV 440 MYKKNHEQLE 450 GNERYEGYCV 460 DLAYEIAKHV 470 RIKYKLSIVG 480 DGKYGARDPE 490 TKIWNGMVGE 500 LVYGRADIAV 510 APLTITLVRE 520 EVIDFSKPFM 530 SLGISIMIKK 540 PQKSKPGVFS 550 FLDPLAYEIW 560 MCIVFAYIGV 570 SVVLFLVSRF 580 SPYEWHLEDN 590 NEEPRDPQSP 600 PDPPNEFGIF 610 NSLWFSLGAF 620 MQQGCDISPR 630 SLSGRIVGGV 640 WWFFTLIIIS 650 SYTANLAAFL 660 TVERMVSPIE 670 SAEDLAKQTE 680 IAYGTLDSGS 690 TKEFFRRSKI 700 AVYEKMWSYM 710 KSAEPSVFTK 720 TTADGVARVR 730 KSKGKFAFLL 740 ESTMNEYIEQ 750 RKPCDTMKVG 760 GNLDSKGYGV 770 ATPKGSALRT 780 PVNLAVLKLS 790 EQGILDKLKN 800 KWWYDKGECG 810 AKDSGSKDKT 820 SALSLSNVAG 830 VFYILVGGLG 840 LAMMVALIEF 850 CYKSRAESKR 860 MKLTKNTQNF 870 KPAPATNTQN 880 YATYREGYNV YGTESVKI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0032281 AMPA glutamate receptor complex
Cellular Component GO:0043198 dendritic shaft
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0098688 parallel fiber to Purkinje cell synapse
Cellular Component GO:0098839 postsynaptic density membrane
Cellular Component GO:0048787 presynaptic active zone membrane
Molecular Function GO:0004971 AMPA glutamate receptor activity
Molecular Function GO:0001540 amyloid-beta binding
Molecular Function GO:0022849 glutamate-gated calcium ion channel activity
Molecular Function GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Molecular Function GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0051290 protein heterotetramerization
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0001919 regulation of receptor recycling
Biological Process GO:0060992 response to fungicide
Biological Process GO:0010226 response to lithium ion

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.