Search Results
Overview
| Uniprot ID | G3V734 |
|---|---|
| Protein Name | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial |
| Gene Name | Decr1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | TAEEITSKTGNKVYA |
Function
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA
Protein Sequence
10
MALLARAFFA
20
GVSRLPCDPG
30
PQRFFSFGTK
40
TLYQSIDAPQ
50
SKFFPPILKP
60
MLPPNAFQGK
70
VAFITGGGTG
80
LGKAMTTFLS
90
SLGAQCVIAS
100
RNIDVLKATA
110
EEITSKTGNK
120
VYAIRCDVRD
130
PDMVHNTVLE
140
LIKVAGHPDV
150
VINNAAGNFI
160
SPSERLSPNG
170
WKTITDIVLN
180
GTAYVTLEIG
190
KQLIKAQKGA
200
AFLAITTIYA
210
ESGSGFVMPS
220
SSAKSGVEAM
230
NKSLAAEWGR
240
YGMRFNIIQP
250
GPIKTKGAFS
260
RLDPTGKFEK
270
DMIERIPCGR
280
LGTVEELANL
290
ATFLCSDYAS
300
WINGAVIRFD
310
GGEEVFLSGE
320
FNSLKKVTKE
330
EWDVIEGLIR
KTKGS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1902494 | catalytic complex |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0008670 | 2,4-dienoyl-CoA reductase (NADPH) activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0070402 | NADPH binding |
| Biological Process | GO:0006635 | fatty acid beta-oxidation |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.