Search Results

Overview

Uniprot ID	G3V746
Protein Name	Glutamate receptor
Gene Name	Grin2b
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1289	PQSPTNSKAQKKNRN

Function

Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system

Protein Sequence

10 MKPSAECCSP 20 KFWLVLAVLA 30 VSGSKARSQK 40 SPPSIGIAVI 50 LVGTSDEVAI 60 KDAHEKDDFH 70 HLSVVPRVEL 80 VAMNETDPKS 90 IITRICDLMS 100 DRKIQGVVFA 110 DDTDQEAIAQ 120 ILDFISAQTL 130 TPILGIHGGS 140 SMIMADKDES 150 SMFFQFGPSI 160 EQQASVMLNI 170 MEEYDWYIFS 180 IVTTYFPGYQ 190 DFVNKIRSTI 200 ENSFVGWELE 210 EVLLLDMSLD 220 DGDSKIQNQL 230 KKLQSPIILL 240 YCTKEEATYI 250 FEVANSVGLT 260 GYGYTWIVPS 270 LVAGDTDTVP 280 SEFPTGLISV 290 SYDEWDYGLP 300 ARVRDGIAII 310 TTAASDMLSE 320 HSFIPEPKSS 330 CYNTHEKRIY 340 QSNMLNRYLI 350 NVTFEGRNLS 360 FSEDGYQMHP 370 KLVIILLNKE 380 RKWERVGKWK 390 DKSLQMKYYV 400 WPRMCPETEE 410 QEDDHLSIVT 420 LEEAPFVIVE 430 SVDPLSGTCM 440 RNTVPCQKRI 450 ISENKTDEEP 460 GYIKKCCKGF 470 CIDILKKISK 480 SVKFTYDLYL 490 VTNGKHGKKI 500 NGTWNGMIGE 510 VVMKRAYMAV 520 GSLTINEERS 530 EVVDFSVPFI 540 ETGISVMVSR 550 SNGTVSPSAF 560 LEPFSADVWV 570 MMFVMLLIVS 580 AVAVFVFEYF 590 SPVGYNRCLA 600 DGREPGGPSF 610 TIGKAIWLLW 620 GLVFNNSVPV 630 QNPKGTTSKI 640 MVSVWAFFAV 650 IFLASYTANL 660 AAFMIQEEYV 670 DQVSGLSDKK 680 FQRPNDFSPP 690 FRFGTVPNGS 700 TERNIRNNYA 710 EMHAYMGKFN 720 QRGVDDALLS 730 LKTGKLDAFI 740 YDAAVLNYMA 750 GRDEGCKLVT 760 IGSGKVFAST 770 GYGIAIQKDS 780 GWKRQVDLAI 790 LQLFGDGEME 800 ELEALWLTGI 810 CHNEKNEVMS 820 SQLDIDNMAG 830 VFYMLGAAMA 840 LSLITFICEH 850 LFYWQFRHCF 860 MGVCSGKPGM 870 VFSISRGIYS 880 CIHGVAIEER 890 QSVMNSPTAT 900 MNNTHSNILR 910 LLRTAKNMAN 920 LSGVNGSPQS 930 ALDFIRRESS 940 VYDISEHRRS 950 FTHSDCKSYN 960 NPPCEENLFS 970 DYISEVERTF 980 GNLQLKDSNV 990 YQDHYHHHHR 1000 PHSIGSTSSI 1010 DGLYDCDNPP 1020 FTTQPRSISK 1030 KPLDIGLPSS 1040 KHSQLSDLYG 1050 KFSFKSDRYS 1060 GHDDLIRSDV 1070 SDISTHTVTY 1080 GNIEGNAAKR 1090 RKQQYKDSLK 1100 KRPASAKSRR 1110 EFDEIELAYR 1120 RRPPRSPDHK 1130 RYFRDKEGLR 1140 DFYLDQFRTK 1150 ENSPHWEHVD 1160 LTDIYKERSD 1170 DFKRDSVSGG 1180 GPCTNRSHLK 1190 HGTGEKHGVV 1200 GGVPAPWEKN 1210 LTNVDWEDRS 1220 GGNFCRSCPS 1230 KLHNYSSTVA 1240 GQNSGRQACI 1250 RCEACKKAGN 1260 LYDISEDNSL 1270 QELDQPAAPV 1280 AVTSNASSTK 1290 YPQSPTNSKA 1300 QKKNRNKLRR 1310 QHSYDTFVDL 1320 QKEEAALAPR 1330 SVSLKDKGRF 1340 MDGSPYAHMF 1350 EMPAGESSFA 1360 NKSSVPTAGH 1370 HHNNPGSGYM 1380 LSKSLYPDRV 1390 TQNPFIPTFG 1400 DDQCLLHGSK 1410 SYFFRQPTVA 1420 GASKTRPDFR 1430 ALVTNKPVVS 1440 ALHGAVPGRF 1450 QKDICIGNQS 1460 NPCVPNNKNP 1470 RAFNGSSNGH 1480 VYEKLSSIES DV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0097542	ciliary tip
Cellular Component	GO:0035869	ciliary transition zone
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005764	lysosome
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex
Cellular Component	GO:0098839	postsynaptic density membrane
Cellular Component	GO:0042734	presynaptic membrane
Molecular Function	GO:0016595	glutamate binding
Molecular Function	GO:0022849	glutamate-gated calcium ion channel activity
Molecular Function	GO:0016594	glycine binding
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004972	NMDA glutamate receptor activity
Biological Process	GO:0001662	behavioral fear response
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol
Biological Process	GO:0060079	excitatory postsynaptic potential
Biological Process	GO:0007612	learning
Biological Process	GO:0060291	long-term synaptic potentiation
Biological Process	GO:0007613	memory
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity
Biological Process	GO:0045471	response to ethanol
Biological Process	GO:0009612	response to mechanical stimulus

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.