Overview
| Uniprot ID | G3V7B6 |
|---|
| Protein Name | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
|---|
| Gene Name | Ptpmt1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 146 |
CNTSKEWKNVGVEQL |
Function
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. Prevents intrinsic apoptosis, by regulating mitochondrial membrane integrity
Protein Sequence
10
MVPVPGSPGP
20
ASDGGDSASE
30
SREASGGPQL
40
SSSASFSRWL
50
TASSEAGGWP
60
LRLAGWGGMA
70
ASAWLEAGLA
80
RVLFYPTLLY
90
TVFRGRVGGP
100
AHRDWYHRID
110
HTVLLGALPL
120
RSMTRRLVLD
130
ENVRGVITMN
140
EEYETRFLCN
150
TSKEWKNVGV
160
EQLRLSTVDM
170
TGVPTLANLH
180
RGVQFALKYQ
190
SLGQCVYVHC
200
KAGRSRSATM
210
VAAYLIQVHN
220
WSPEEAIEAI
230
AKIRSHISIR
240
PSQLEILKEF
250
HKEIAARAAK
N
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Molecular Function |
GO:0008962 |
phosphatidylglycerophosphatase activity |
| Molecular Function |
GO:0004722 |
protein serine/threonine phosphatase activity |
| Biological Process |
GO:0032049 |
cardiolipin biosynthetic process |
| Biological Process |
GO:0043653 |
mitochondrial fragmentation involved in apoptotic process |
| Biological Process |
GO:2001242 |
regulation of intrinsic apoptotic signaling pathway |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.