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Overview

Uniprot ID	G3V7G0
Protein Name	Dynein light intermediate chain
Gene Name	Dync1li1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
385	KLQSLLAKQPPTAAG
428	SPIPAGSKKIDPNMK
485	SLPPSAKKSGQKPVL

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes

Protein Sequence

10 MAAVGRVGSF 20 GSSPPGLAST 30 YASGPLANEL 40 ASGSGGPAAG 50 DDEDGQNLWS 60 CILSEVSTRS 70 RSKLPTGKNV 80 LLLGEDGAGK 90 TSLIRRIQGI 100 EEYKKGRGLE 110 YLYLNVHDED 120 RDDQTRCNVW 130 ILDGDLYHKG 140 LLKFSLDALS 150 LRDTLVMLVV 160 DMSKPWTALD 170 SLQKWASVVR 180 EHVDKLKIPP 190 EEMKEMEQKL 200 IRDFQEYVEP 210 GEDFPASPQR 220 RATAAQEDRD 230 DSVVLPLGAD 240 TLTHNLGLPV 250 LVVCTKCDAI 260 SVLEKEHDYR 270 DEHFDFIQSH 280 IRKFCLQYGA 290 ALIYTSVKEN 300 KNIDLVYKYI 310 VQKLYGFPYK 320 IPAVVVEKDA 330 VFIPAGWDND 340 KKIGILHENF 350 QTLKIEDNFE 360 DIITKPPVRK 370 FVHEKEIMAE 380 DDQVFLMKLQ 390 SLLAKQPPTA 400 AGRPVDASPR 410 VPGGSPRTPN 420 RSVSSNVASV 430 SPIPAGSKKI 440 DPNMKAGATS 450 EGVLANFFNS 460 LLSKKTGSPG 470 GPGVGGSPGG 480 GAAGASTSLP 490 PSAKKSGQKP 500 VLSDVHAELD 510 RITRKPASVS 520 PTTPPSPTEG EAS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005868	cytoplasmic dynein complex
Cellular Component	GO:0030666	endocytic vesicle membrane
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0000922	spindle pole
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0045504	dynein heavy chain binding
Molecular Function	GO:0019003	GDP binding
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Biological Process	GO:0061502	early endosome to recycling endosome transport
Biological Process	GO:0007018	microtubule-based movement
Biological Process	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint
Biological Process	GO:0060627	regulation of vesicle-mediated transport

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.