Search Results
Overview
| Uniprot ID | G3V7I0 |
|---|---|
| Protein Name | Thioredoxin-dependent peroxide reductase, mitochondrial |
| Gene Name | Prdx3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 254 | ASKEYFEKVHQ**** |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength
Protein Sequence
10
MAAAAGRLLW
20
SSVARPASTI
30
FRSISASTVL
40
RPVASRRTCL
50
TDMLWSACPQ
60
AKFAFSTSSS
70
FHTPAVTQHA
80
PHFKGTAVVN
90
GEFKELSLDD
100
FKGKYLVLFF
110
YPLDFTFVCP
120
TEIVAFSDKA
130
NEFHDVNCEV
140
VAVSVDSHFS
150
HLAWINTPRK
160
NGGLGHMNIT
170
LLSDLTKQIS
180
RDYGVLLESA
190
GIALRGLFII
200
DPNGVIKHLS
210
VNDLPVGRSV
220
EETLRLVKAF
230
QFVETHGEVC
240
PANWTPESPT
250
IKPSPTASKE
YFEKVHQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0140824 | thioredoxin-dependent peroxiredoxin activity |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.