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Overview

Uniprot ID	G3V7L6
Protein Name	26S proteasome regulatory subunit 7
Gene Name	Psmc2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
116	PKYIINVKQFAKFVV

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides

Protein Sequence

10 MPDYLGADQR 20 KTKEDEKDDK 30 PIRALDEGDI 40 ALLKTYGQST 50 YSRQIKQVED 60 DIQQLLKKIN 70 ELTGIKESDT 80 GLAPPALWDL 90 AADKQTLQSE 100 QPLQVARCTK 110 IINADSEDPK 120 YIINVKQFAK 130 FVVDLSDQVA 140 PTDIEEGMRV 150 GVDRNKYQIH 160 IPLPPKIDPT 170 VTMMQVEEKP 180 DVTYSDVGGC 190 KEQIEKLREV 200 VETPLLHPER 210 FVNLGIEPPK 220 GVLLFGPPGT 230 GKTLCARAVA 240 NRTDACFIRV 250 IGSELVQKYV 260 GEGARMVREL 270 FEMARTKKAC 280 LIFFDEIDAI 290 GGARFDDGAG 300 GDNEVQRTML 310 ELINQLDGFD 320 PRGNIKVLMA 330 TNRPDTLDPA 340 LMRPGRLDRK 350 IEFSLPDLEG 360 RTHIFKIHAR 370 SMSVERDIRF 380 ELLARLCPNS 390 TGAEIRSVCT 400 EAGMFAIRAR 410 RKIATEKDFL 420 EAVNKVIKSY 430 AKFSATPRYM TYN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0000932	P-body
Cellular Component	GO:0022624	proteasome accessory complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0036402	proteasome-activating activity
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.