Search Results

Overview

Uniprot ID	G3V7L8
Protein Name	-
Gene Name	Atp6v1e1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
10	LSDADVQKQIKHMMA
107	QRLSKVVKDTTRYQV
138	RMIVRCRKQDFPLVK
150	LVKAAVQKAIPMYKI
156	QKAIPMYKIATKKDV
191	YNGDRKIKVSNTLES
33	KAEEIDAKAEEEFNI
42	EEEFNIEKGRLVQTQ
52	LVQTQRLKIMEYYEK
69	KQIEQQKKIQMSNLM

Function

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment

Protein Sequence

10 MALSDADVQK 20 QIKHMMAFIE 30 QEANEKAEEI 40 DAKAEEEFNI 50 EKGRLVQTQR 60 LKIMEYYEKK 70 EKQIEQQKKI 80 QMSNLMNQAR 90 LKVLRARDDL 100 ITDLLNEAKQ 110 RLSKVVKDTT 120 RYQVLLDGLV 130 LQGLYQLLEP 140 RMIVRCRKQD 150 FPLVKAAVQK 160 AIPMYKIATK 170 KDVDVQIDQE 180 AYLPEDIAGG 190 VEIYNGDRKI 200 KVSNTLESRL 210 DLIAQQMMPE 220 VRGALFGANA NRKFLD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
Molecular Function	GO:0046961	proton-transporting ATPase activity, rotational mechanism

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.