Search Results
Overview
| Uniprot ID | G3V7P1 |
|---|---|
| Protein Name | Syntaxin-12 |
| Gene Name | Stx12 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 53 | LMSQLGTKQDSSKLQ |
Function
SNARE promoting fusion of transport vesicles with target membranes (PubMed:17159904, PubMed:30962439). Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway (PubMed:30962439). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (PubMed:16037816)
Protein Sequence
10
MSYGPLDMYR
20
NPGPSGPQPR
30
DFNSIIQTCS
40
GNIQRISQAT
50
AQIKNLMSQL
60
GTKQDSSKLQ
70
ENLQQFQHST
80
NQLAKETNEL
90
LKELGSLPLP
100
LSASEQRQQK
110
LQKERLMNDF
120
SSALNNFQVV
130
QRKVSEKEKE
140
SIARARAGSR
150
LSAEDRQREE
160
QLVSFDSHEE
170
WNQMQSQEEE
180
AAITEQDLEL
190
IKERETAIQQ
200
LEADILDVNQ
210
IFKDLAMMIH
220
DQGDLIDSIE
230
ANVESSEVHV
240
ERASDQLQRA
250
AYYQKKSRKK
260
MCILVLVLSV
270
IVTVLVVVIW
VASK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031083 | BLOC-1 complex |
| Biological Process | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels |
| Biological Process | GO:0016189 | synaptic vesicle to endosome fusion |
| Biological Process | GO:0048278 | vesicle docking |
| Biological Process | GO:0006906 | vesicle fusion |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0045335 | phagocytic vesicle |
| Cellular Component | GO:0000407 | phagophore assembly site |
| Cellular Component | GO:0098837 | postsynaptic recycling endosome |
| Cellular Component | GO:0098944 | postsynaptic recycling endosome membrane |
| Cellular Component | GO:0055037 | recycling endosome |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Cellular Component | GO:0031201 | SNARE complex |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0005484 | SNAP receptor activity |
| Molecular Function | GO:0000149 | SNARE binding |
| Biological Process | GO:0000045 | autophagosome assembly |
| Biological Process | GO:0033344 | cholesterol efflux |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0050821 | protein stabilization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.