Overview
| Uniprot ID | G3V7Q6 |
|---|
| Protein Name | Proteasome subunit beta |
|---|
| Gene Name | Psmb5 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 91 |
YIASQTVKKVIEINP |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity
Protein Sequence
10
MALASVLQRP
20
MPVNQHGFFG
30
LGGRADLLDL
40
GPGSPGDGLS
50
LAAPSWGVPE
60
EPRIEMLHGT
70
TTLAFKFQHG
80
VIVAADSRAT
90
AGAYIASQTV
100
KKVIEINPYL
110
LGTMAGGAAD
120
CSFWERLLAR
130
QCRIYELRNK
140
ERISVAAASK
150
LLANMVYQYK
160
GMGLSMGTMI
170
CGWDKRGPGL
180
YYVDSEGNRI
190
SGTAFSVGSG
200
SVYAFGVMDR
210
GYSYDLQVEE
220
AYDLARRAIY
230
QATYRDAYSG
240
GAVNLYHVRE
250
DGWIRVSSDN
260
VADLHDKYTS
SIP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005839 |
proteasome core complex |
| Molecular Function |
GO:0004298 |
threonine-type endopeptidase activity |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0061136 |
regulation of proteasomal protein catabolic process |
| Biological Process |
GO:0006979 |
response to oxidative stress |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.