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Overview

Uniprot IDG3V7S2
Protein NameNeurofilament medium polypeptide
Gene NameNefm
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
100 KLSRSNEKEQLQGLN
125 HYLEQQNKEIEAEIH
166 LEMVNHEKAQVQLDS
206 AAIRALRKDIEESSM
221 VKVELDKKVQSLQDE
261 VERKDYLKTDISTAL
269 TDISTALKEIRSQLE
296 WFKCRYAKLTEAAEQ
305 TEAAEQNKEAIRSAK
312 KEAIRSAKEEIAEYR
325 YRRQLQSKSIELESV
372 ENELRGTKWEMARHL
434 PSVTISSKIQKTKVE
444 KTKVEAPKLKVQHKF
450 PKLKVQHKFVEEIIE
53 STVSSSYKRSALAPR
583 IKVEKPEKAKSPVPK
623 EEKKEVAKESPKEEK
684 EKPQQQEKVKEKAEE
811 EKLVSTKKVEKVTSH

Function

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks

Protein Sequence

10 MSYTLDSLGN 20 PSAYRRVTET 30 RSSFSRVSGS 40 PSSGFRSQSW 50 SRGSPSTVSS 60 SYKRSALAPR 70 LAYSSAMLSS 80 AESSLDFSQS 90 SSLLNGGSGG 100 DYKLSRSNEK 110 EQLQGLNDRF 120 AGYIEKVHYL 130 EQQNKEIEAE 140 IHALRQKQAS 150 HAQLGDAYDQ 160 EIRELRATLE 170 MVNHEKAQVQ 180 LDSDHLEEDI 190 HRLKERFEEE 200 ARLRDDTEAA 210 IRALRKDIEE 220 SSMVKVELDK 230 KVQSLQDEVA 240 FLRSNHEEEV 250 ADLLAQIQAS 260 HITVERKDYL 270 KTDISTALKE 280 IRSQLECHSD 290 QNMHQAEEWF 300 KCRYAKLTEA 310 AEQNKEAIRS 320 AKEEIAEYRR 330 QLQSKSIELE 340 SVRGTKESLE 350 RQLSDIEERH 360 NHDLSSYQDT 370 IQQLENELRG 380 TKWEMARHLR 390 EYQDLLNVKM 400 ALDIEIAAYR 410 KLLEGEETRF 420 STFSGSITGP 430 LYTHRQPSVT 440 ISSKIQKTKV 450 EAPKLKVQHK 460 FVEEIIEETK 470 VEDEKSEMED 480 ALTVIAEELA 490 ASAKEEKEEA 500 EEKEEEPEVE 510 KSPVKSPEAK 520 EEEEGEKEEE 530 EEGQEEEEEE 540 DEGVKSDQAE 550 EGGSEKEGSS 560 EKDEGEQEEE 570 GETEGKVEEM 580 AIKEEIKVEK 590 PEKAKSPVPK 600 SPVEEVKPKP 610 EAKAGKDEQK 620 EEEKVEEKKE 630 VAKESPKEEK 640 VEKKEEKPKD 650 VPDKKKAESP 660 VKEKAVEEMI 670 TITKSVKVSL 680 EKDTKEEKPQ 690 QQEKVKEKAE 700 EEGGSEEEVG 710 DKSPQESKKE 720 DIAINGEVEG 730 KEEEEQETQE 740 KGSGQEEEKG 750 VVTNGLDVSP 760 AEEKKGEDRS 770 DDKVVVTKKV 780 EKITSEGGDG 790 ATKYITKSVT 800 VTQKVEEHEE 810 TFEEKLVSTK 820 KVEKVTSHAI VKEVTQGD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005882 intermediate filament
Cellular Component GO:0097418 neurofibrillary tangle
Molecular Function GO:0005198 structural molecule activity

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.