Search Results

Overview

Uniprot ID	G3V7U4
Protein Name	Lamin-B1
Gene Name	Lmnb1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
111	QIELGKFKAEHDQLL
124	LLLNYAKKESDLSGA
134	DLSGAQIKLREYEAA
182	ASLSAAKKQLADETL
261	DAQVRLYKEELEQTY
49	RLAVYIDKVRSLETE

Function

Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively

Protein Sequence

10 MATATPVQQR 20 AGSRASAPAT 30 PLSPTRLSRL 40 QEKEELRELN 50 DRLAVYIDKV 60 RSLETENSAL 70 QLQVTEREEV 80 RGRELTGLKA 90 LYETELADAR 100 RALDDTARER 110 AKLQIELGKF 120 KAEHDQLLLN 130 YAKKESDLSG 140 AQIKLREYEA 150 ALNSKDAALA 160 TALGDKKSLE 170 GDLEDLKDQI 180 AQLEASLSAA 190 KKQLADETLL 200 KVDLENRCQS 210 LTEDLEFRKN 220 MYEEEINETR 230 RKHETRLVEV 240 DSGRQIEYEY 250 KLAQALHEMR 260 EQHDAQVRLY 270 KEELEQTYHA 280 KLENARLSSE 290 MNTSTVNSAR 300 EELMESRMRI 310 ESLSSQLSNL 320 QKESRACLER 330 IQELEDMLAK 340 ERDNSRRMLS 350 DKEREMAEIR 360 DQMQQQLNDY 370 EQLLDVKLAL 380 DMEISAYRKL 390 LEGEEERLKL 400 SPSPSSRVTV 410 SRASSSRSVR 420 TTRGKRKRVD 430 VEESEASSSV 440 SISHSASATG 450 NVCIEEIDVD 460 GKFIRLKNTS 470 EQDQPMGGWE 480 MIRKIGDTSV 490 SYKYTSRYVL 500 KAGQTVTVWA 510 ANAGVTASPP 520 TDLIWKNQNS 530 WGTGEDVKVV 540 LKNSQGEEVA 550 QRSTVFKTTI 560 PEEEEEEEEE 570 PIGVAIEEER 580 FHQQGTPRAS NKSCAIM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005638	lamin filament
Cellular Component	GO:0005637	nuclear inner membrane
Cellular Component	GO:0016363	nuclear matrix
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0043274	phospholipase binding
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding
Molecular Function	GO:0160123	structural constituent of nuclear lamina
Biological Process	GO:0006998	nuclear envelope organization

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.