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Overview

Uniprot ID	G3V864
Protein Name	Phospholipid phosphatase-related protein type 4
Gene Name	Plppr4
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
565	KWLKAAEKTVACNRG
756	NTRNIFYKGTSPTRA

Function

Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane. Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse

Protein Sequence

10 MQRAGSSGAR 20 GECDISGTGR 30 LRLEQAARLG 40 GRAVHTSPTG 50 GLGARQVAGM 60 SAKERPKGKV 70 IKDSVTLLPC 80 FYFVELPILA 90 SSVVSLYFLE 100 LTDVFKPVHS 110 GFSCYDRSLS 120 MPYIEPTQEA 130 IPFLMLLSLA 140 FAGPAITIMV 150 GEGILYCCLS 160 KRRNGAGLEP 170 NINAGGCNFN 180 SFLRRAVRFV 190 GVHVFGLCST 200 ALITDIIQLS 210 TGYQAPYFLT 220 VCKPNYTSLN 230 VSCKENSYIV 240 EDICSGSDLT 250 VINSGRKSFP 260 SQHATLAAFA 270 AVYVSMYFNS 280 TLTDSSKLLK 290 PLLVFTFIIC 300 GIICGLTRIT 310 QYKNHPVDVY 320 CGFLIGGGIA 330 LYLGLYAVGN 340 FLPSEDSMLQ 350 HRDALRSLTD 360 LNQDPSRVLS 370 AKNGSSGDGI 380 AHTEGILNRN 390 HRDASSLTNL 400 KRANADVEII 410 TPRSPMGKES 420 MVTFSNTLPR 430 ANTPSVEDPV 440 RRNASIHASM 450 DSARSKQLLT 460 QWKSKNESRK 470 MSLQVMDSEP 480 EGQSPPRSIE 490 MRSSSEPSRV 500 GVNGDHHVPG 510 NQYLKIQPGT 520 VPGCNNSMPA 530 GPRVSIQSRP 540 GSSQLVHIPE 550 ETQENISTSP 560 KSSSARAKWL 570 KAAEKTVACN 580 RGNNQPRIMQ 590 VIAMSKQQGV 600 LQSSPKNAEG 610 STVTCTGSIR 620 YKTLTDHEPS 630 GIVRVEAHPE 640 NNRPIIQIPS 650 STEGEGSGSW 660 KWKAPEKSSL 670 RQTYELNDLN 680 RDSESCESLK 690 DSFGSGDRKR 700 SNIDSNEHHH 710 HGITTIRVTP 720 VEGSEIGSET 730 LSVSSSRDST 740 LRRKGNIILI 750 PERSNSPENT 760 RNIFYKGTSP TRAYKD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0098839	postsynaptic density membrane
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse
Biological Process	GO:0140354	lipid import into cell
Biological Process	GO:0006644	phospholipid metabolic process
Biological Process	GO:0099175	regulation of postsynapse organization
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.