Search Results

Overview

Uniprot ID	G3V888
Protein Name	ATP-citrate synthase
Gene Name	Acly
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
4	****MSAKAISEQTG
468	ADEVAPAKKAKPAMP
978	MGIGHRVKSINNPDM

Function

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism

Protein Sequence

10 MSAKAISEQT 20 GKELLYKYIC 30 TTSAIQNRFK 40 YARVTPDTDW 50 AHLLQDHPWL 60 LSQSLVVKPD 70 QLIKRRGKLG 80 LVGVNLSLDG 90 VKSWLKPRLG 100 HEATVGKAKG 110 FLKNFLIEPF 120 VPHSQAEEFY 130 VCIYATREGD 140 YVLFHHEGGV 150 DVGDVDTKAQ 160 KLLVGVDEKL 170 NAEDIKRHLL 180 VHAPEDKKEI 190 LASFISGLFN 200 FYEDLYFTYL 210 EINPLVVTKD 220 GVYILDLAAK 230 VDATADYICK 240 VKWGDIEFPP 250 PFGREAYPEE 260 AYIADLDAKS 270 GASLKLTLLN 280 PKGRIWTMVA 290 GGGASVVYSD 300 TICDLGGVNE 310 LANYGEYSGA 320 PSEQQTYDYA 330 KTILSLMTRE 340 KHPDGKILII 350 GGSIANFTNV 360 AATFKGIVRA 370 IRDYQGPLKE 380 HEVTIFVRRG 390 GPNYQEGLRV 400 MGEVGKTTGI 410 PIHVFGTETH 420 MTAIVGMALG 430 HRPIPNQPPT 440 AAHTANFLLN 450 ASGSTSTPAP 460 SRTASFSESR 470 ADEVAPAKKA 480 KPAMPQDSVP 490 SPRSLQGKSA 500 TLFSRHTKAI 510 VWGMQTRAVQ 520 GMLDFDYVCS 530 RDEPSVAAMV 540 YPFTGDHKQK 550 FYWGHKEILI 560 PVFKNMADAM 570 KKHPEVDVLI 580 NFASLRSAYD 590 STMETMNYAQ 600 IRTIAIIAEG 610 IPEALTRKLI 620 KKADQKGVTI 630 IGPATVGGIK 640 PGCFKIGNTG 650 GMLDNILASK 660 LYRPGSVAYV 670 SRSGGMSNEL 680 NNIISRTTDG 690 VYEGVAIGGD 700 RYPGSTFMDH 710 VLRYQDTPGV 720 KMIVVLGEIG 730 GTEEYKICRG 740 IKEGRLTKPV 750 VCWCIGTCAT 760 MFSSEVQFGH 770 AGACANQASE 780 TAVAKNQALK 790 EAGVFVPRSF 800 DELGEIIQSV 810 YEDLVAKGAI 820 VPAQEVPPPT 830 VPMDYSWARE 840 LGLIRKPASF 850 MTSICDERGQ 860 ELIYAGMPIT 870 EVFKEEMGIG 880 GVLGLLWFQR 890 RLPKYSCQFI 900 EMCLMVTADH 910 GPAVSGAHNT 920 IICARAGKDL 930 VSSLTSGLLT 940 IGDRFGGALD 950 AAAKMFSKAF 960 DSGIIPMEFV 970 NKMKKEGKLI 980 MGIGHRVKSI 990 NNPDMRVQIL 1000 KDFVKQHFPA 1010 TPLLDYALEV 1020 EKITTSKKPN 1030 LILNVDGFIG 1040 VAFVDMLRNC 1050 GSFTREEADE 1060 YVDIGALNGV 1070 FVLGRSMGFI 1080 GHYLDQKRLK 1090 QGLYRHPWDD 1100 ISYVLPEHMS M

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003878	ATP citrate synthase activity
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006085	acetyl-CoA biosynthetic process
Biological Process	GO:0006101	citrate metabolic process
Biological Process	GO:0006633	fatty acid biosynthetic process
Biological Process	GO:0110076	negative regulation of ferroptosis
Biological Process	GO:0006107	oxaloacetate metabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.