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Overview

Uniprot ID	G3V8B6
Protein Name	26S proteasome non-ATPase regulatory subunit 1
Gene Name	Psmd1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
148	CLDDHKYKQAIGIAL

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

Protein Sequence

10 MITSAAGIIS 20 LLDEEEPQLK 30 EFALHKLNAV 40 VNDFWAEISE 50 SVDKIEVLYE 60 DEGFRSRQFA 70 ALVASKVFYH 80 LGAFEESLNY 90 ALGAGDLFNV 100 NDNSEYVETI 110 IAKCIDHYTK 120 QCVENADLPE 130 GEKKPIDQRL 140 EGIVNKMFQR 150 CLDDHKYKQA 160 IGIALETRRL 170 DVFEKTILES 180 NDVPGMLAYS 190 LKLCMSLMQN 200 KQFRNKVLRV 210 LVKIYMNLEK 220 PDFINVCQCL 230 IFLDDPQAVS 240 DILEKLVKED 250 NLLMAYQICF 260 DLYESASQQF 270 LSSVIQNLRT 280 VGTPIASVPG 290 STNTGTVPGP 300 EKDSDSMETE 310 EKTAGAVAGK 320 TPDASPEPKD 330 QTLKMIKILS 340 GEMAIELHLQ 350 FLIRNNNTDL 360 MILKNTKDAV 370 RNSVCHTATV 380 IANSFMHCGT 390 TSDQFLRDNL 400 EWLARATNWA 410 KFTATASLGV 420 IHKGHEKEAL 430 QLMATYLPKD 440 TSPGSAYQEG 450 GGLYALGLIH 460 ANHGGDIIDY 470 LLNQLKNASN 480 DIVRHGGSLG 490 LGLAAMGTAR 500 QDVYDLLKTN 510 LYQDDAVTGE 520 AAGLALGLVM 530 LGSKNAQAIE 540 DMVGYAQETQ 550 HEKILRGLAV 560 GIALVMYGRM 570 EEADALIESL 580 CRDKDPILRR 590 SGMYTVAMAY 600 CGSGNNKAIR 610 RLLHVAVSDV 620 NDDVRRAAVE 630 SLGFILFRTP 640 EQCPSVVSLL 650 SESYNPHVRY 660 GAAMALGVCC 670 AGTGNKEAIN 680 LLEPMTNDPV 690 NYVRQGALIA 700 SALIMIQQTE 710 ITCPKVNQFR 720 QLYSKVINDK 730 HDDVMAKFGA 740 ILAQGILDAG 750 GHNVTISLQS 760 RTGHTHMPSV 770 VGVLVFTQFW 780 FWFPLSHFLS 790 LAYTPTCVIG 800 LNKDLKMPKV 810 QYKSNCKPST 820 FAYPAPLEVP 830 KEKEKEKVST 840 AVLSITAKAK 850 KKEKEKEKKE 860 EEKMEVDEAE 870 KKEEKEKKKE 880 PEPNFQLLDN 890 PARVMPAQLK 900 VLSMTETCRY 910 QPFKPLSIGG 920 IIILKDTSED 930 IEELVEPVAA 940 HGPKIEEEEQ 950 EPEPPEPFEY IDD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0008540	proteasome regulatory particle, base subcomplex
Molecular Function	GO:0030234	enzyme regulator activity
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Biological Process	GO:0042176	regulation of protein catabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.