Overview
| Uniprot ID | G3V8E2 |
|---|
| Protein Name | Striatin-interacting protein 1 |
|---|
| Gene Name | Strip1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 102 |
GGLLPAGKAREFNRN |
Function
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation
Protein Sequence
10
MTKKGKTSGG
20
DWQLRLSTHA
30
ATLNMAIGEI
40
SWRKSRESCL
50
TEAIRELSRG
60
CGAAKMEPAA
70
AGPGPLIVNN
80
KQPQPPPPPP
90
PATAQPPPGA
100
PRAAGGLLPA
110
GKAREFNRNQ
120
RKDSEGYSES
130
PDLEFEYADT
140
DKWAAELAEL
150
YSYTEGPEFL
160
MNRKCFEEDF
170
RIHVTDKKWT
180
ELDTNQHRTH
190
AMRLLDGLEV
200
TAREKRLKVA
210
RAILYVAQGT
220
FGECSSEAEV
230
QFWMRYNIFL
240
LLEVGTFNAL
250
VELLNMEIDN
260
SAACSSAVRK
270
PAISLADSTD
280
LRVLLNIMYL
290
IVETVHQDCD
300
GDKAEWRTMR
310
QTFRAELGSP
320
LYNNEPFAIM
330
LFGMVTKFCS
340
GHAPHFPMKK
350
VLLLLWKTVL
360
CTLGGFEELQ
370
SMKAEKRTLL
380
GLPPLPEDSI
390
KVIRNMRAAS
400
PPASASDLIE
410
QQQKRGRREH
420
KALIKQDNLD
430
AFNERDPYKA
440
DDSREEEEEN
450
DDDNSLEGEA
460
FPLERDEVMP
470
PPLQHPPTDR
480
LTCPKGLPWA
490
PKVREKDIEM
500
FLESSRSKFI
510
GYTLGSDTDT
520
VVGLPRPIHE
530
SIKTLKQHKY
540
TSIAEVQAQM
550
EEEYLRSPLS
560
GGEEEVEQVP
570
AETLYQGLLP
580
SLPQYMIALL
590
KILLAAAPTS
600
KAKTDSINIL
610
ADVLPEEMPT
620
TVLQSMKLGV
630
DVNRHKEVIV
640
KAISAVLLLL
650
LKHFKLNHIY
660
QFEYMAQHLV
670
FANCIPLILK
680
FFNQNIMSYI
690
TAKNSISVLD
700
YPHCVVNELP
710
ELTAESLEAG
720
DNNQFCWRNL
730
FSCINLLRIL
740
NKLTKWKHSR
750
TMMLVVFKSA
760
PILKRALKVK
770
QAMMQLYVLK
780
LLKVQTKYLG
790
RQWRKSNMKT
800
MSAIYQKVRH
810
RLNDDWAYGN
820
DLDARPWDFQ
830
AEECALRANI
840
ERFNARRYDR
850
THSNPDFLPV
860
DNCLQSVLGQ
870
RVDLPEDFQM
880
NYDLWLEREV
890
FSKPISWEEL
LQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0090443 |
FAR/SIN/STRIPAK complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Biological Process |
GO:0007010 |
cytoskeleton organization |
| Biological Process |
GO:0035331 |
negative regulation of hippo signaling |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.