Search Results

Overview

Uniprot ID	G3V8L3
Protein Name	Prelamin-A/C
Gene Name	Lmna
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
260	LKARNTKKEGDLLAA

Function

Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence

Protein Sequence

10 MLGLKACATM 20 PGFRLYFLKR 30 PFLQSQKSGT 40 WCPSHVLNAR 50 TALDGSFKSS 60 GSTPCGGGPI 70 RVSARLSVTQ 80 CSRERCLSLN 90 TSQPRSRGAP 100 APSPDLHACQ 110 ERASPARCPP 120 SSLCPSVRVP 130 RPSRDPCPAG 140 STATLPAMET 150 PSQRRATRSG 160 AQASSTPLSP 170 TRITRLQEKE 180 DLQELNDRLA 190 VYIDRVRSLE 200 TENAGLRLRI 210 TESEEVVSRE 220 VSGIKAAYEA 230 ELGDARKTLD 240 SVAKERARLQ 250 LELSKVREEF 260 KELKARNTKK 270 EGDLLAAQAR 280 LKDLEALLNS 290 KEAALSTALS 300 EKRTLEGELH 310 DLRGQVAKLE 320 AALGEAKKQL 330 QDEMLRRVDA 340 ENRLQTLKEE 350 LDFQKNIYSE 360 ELRETKRRHE 370 TRLVEIDNGK 380 QREFESRLAD 390 ALQELRAQHE 400 DQVEQYKKEL 410 EKTYSAKLDN 420 ARQSAERNSN 430 LVGAAHEELQ 440 QSRIRIDSLS 450 AQLSQLQKQL 460 AAKEAKLRDL 470 EDSLARERDT 480 SRRLLAEKER 490 EMAEMRARMQ 500 QQLDEYQELL 510 DIKLALDMEI 520 HAYRKLLEGE 530 EERLRLSPSP 540 TSQRSRGRAS 550 SHSSQSQGGG 560 SVTKKRKLES 570 SESRSSFSQH 580 ARTSGRVAVE 590 EVDEEGKFVR 600 LRNKSNEDQS 610 MGNWQIRRQN 620 GDDPLMTYRF 630 PPKFTLKAGQ 640 VVTIWASGAG 650 ATHSPPTDLV 660 WKAQNTWGCG 670 SSLRTALINA 680 TGEEVAMRKL 690 VRSLTMVEDN 700 DDEEEDGDEL 710 LHHHRGSHCS 720 SSGDPAEYNL 730 RSRTVLCGTC 740 GQPADKAASG 750 SGAQVGGSIS 760 SGSSASSVTV 770 TRSFRSVGGS 780 GGGSFGDNLV 790 TRSYLLGNSS 800 PRTQSSQNCS IM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005882	intermediate filament
Cellular Component	GO:0005652	nuclear lamina
Cellular Component	GO:0016363	nuclear matrix
Cellular Component	GO:0005654	nucleoplasm

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.