Search Results
Overview
| Uniprot ID | G3V913 |
|---|---|
| Protein Name | Heat shock protein beta-1 |
| Gene Name | Hspb1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | EELTVKTKEGVVEIT |
| 127 | GVVEITGKHEERQDE |
Function
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins
Protein Sequence
10
MTERRVPFSL
20
LRSPSWEPFR
30
DWYPAHSRLF
40
DQAFGVPRFP
50
DEWSQWFSSA
60
GWPGYVRPLP
70
AATAEGPAAV
80
TLAAPAFSRA
90
LNRQLSSGVS
100
EIRQTADRWR
110
VSLDVNHFAP
120
EELTVKTKEG
130
VVEITGKHEE
140
RQDEHGYISR
150
CFTRKYTLPP
160
GVDPTLVSSS
170
LSPEGTLTVE
180
APLPKAVTQS
190
AEITIPVTFE
200
ARAQIGGPES
EQSGAK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005819 | spindle |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Molecular Function | GO:0008426 | protein kinase C inhibitor activity |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Biological Process | GO:0099641 | anterograde axonal protein transport |
| Biological Process | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| Biological Process | GO:0060729 | intestinal epithelial structure maintenance |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0090038 | negative regulation of protein kinase C signaling |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| Biological Process | GO:2001028 | positive regulation of endothelial cell chemotaxis |
| Biological Process | GO:0032731 | positive regulation of interleukin-1 beta production |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0043122 | regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0009615 | response to virus |
| Biological Process | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.