Search Results
Overview
| Uniprot ID | G3V992 |
|---|---|
| Protein Name | General transcription factor IIE subunit 1 |
| Gene Name | Gtf2e1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 330 | RALLIHEKKTSSATA |
Function
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase
Protein Sequence
10
MADPDVLTEV
20
PAALKRLAKY
30
VIRGFYGIEH
40
VLALDILIRN
50
PCVKEEDMLE
60
LLKFDRKQLR
70
SVLNNLKGDK
80
FIKCRMRVET
90
AADGKTTRHN
100
YYFINYRTLV
110
NVVKYKLDHM
120
RRRIETDERN
130
STNRASFKCP
140
VCCSTFTDLE
150
ANQLFEPMTG
160
TFRCTFCQAE
170
VEEDESAMPK
180
KDARTLLARF
190
NEQIEPIYAL
200
LRETEDVNLA
210
YEILEPEPTE
220
IPALKQSKDR
230
AASAAGAAGL
240
AGGHHREAWT
250
NKGPSYEDLY
260
TQNVVISMDD
270
QDDVHRTSLE
280
GKAAKERPIW
290
LRESTVQGAY
300
GSEEMKEGGI
310
DMDTFQDREE
320
ARAGPDDNEE
330
VMRALLIHEK
340
KTSSATAGSV
350
GAAAPVTAAN
360
GSDSESETSE
370
SDDDSPPRPA
380
AAAPHHRDED
390
EEDDEFEEVA
400
DDPVVMVAGC
410
PFSYSEVSQR
420
PELVAQMTPE
430
EKEAYIAMGQ
RMFEDLFE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005669 | transcription factor TFIID complex |
| Cellular Component | GO:0005673 | transcription factor TFIIE complex |
| Molecular Function | GO:0016251 | RNA polymerase II general transcription initiation factor activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0051123 | RNA polymerase II preinitiation complex assembly |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
| Biological Process | GO:0006367 | transcription initiation at RNA polymerase II promoter |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.