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Overview

Uniprot IDG3V9G4
Protein NameATP-citrate synthase
Gene NameAcly
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
4 ****MSAKAISEQTG
468 ADEVAPAKKAKPAMP
968 MGIGHRVKSINNPDM

Function

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism

Protein Sequence

10 MSAKAISEQT 20 GKELLYKYIC 30 TTSAIQNRFK 40 YARVTPDTDW 50 AHLLQDHPWL 60 LSQSLVVKPD 70 QLIKRRGKLG 80 LVGVNLSLDG 90 VKSWLKPRLG 100 HEATVGKAKG 110 FLKNFLIEPF 120 VPHSQAEEFY 130 VCIYATREGD 140 YVLFHHEGGV 150 DVGDVDTKAQ 160 KLLVGVDEKL 170 NAEDIKRHLL 180 VHAPEDKKEI 190 LASFISGLFN 200 FYEDLYFTYL 210 EINPLVVTKD 220 GVYILDLAAK 230 VDATADYICK 240 VKWGDIEFPP 250 PFGREAYPEE 260 AYIADLDAKS 270 GASLKLTLLN 280 PKGRIWTMVA 290 GGGASVVYSD 300 TICDLGGVNE 310 LANYGEYSGA 320 PSEQQTYDYA 330 KTILSLMTRE 340 KHPDGKILII 350 GGSIANFTNV 360 AATFKGIVRA 370 IRDYQGPLKE 380 HEVTIFVRRG 390 GPNYQEGLRV 400 MGEVGKTTGI 410 PIHVFGTETH 420 MTAIVGMALG 430 HRPIPNQPPT 440 AAHTANFLLN 450 ASGSTSTPAP 460 SRTASFSESR 470 ADEVAPAKKA 480 KPAMPQGKSA 490 TLFSRHTKAI 500 VWGMQTRAVQ 510 GMLDFDYVCS 520 RDEPSVAAMV 530 YPFTGDHKQK 540 FYWGHKEILI 550 PVFKNMADAM 560 KKHPEVDVLI 570 NFASLRSAYD 580 STMETMNYAQ 590 IRTIAIIAEG 600 IPEALTRKLI 610 KKADQKGVTI 620 IGPATVGGIK 630 PGCFKIGNTG 640 GMLDNILASK 650 LYRPGSVAYV 660 SRSGGMSNEL 670 NNIISRTTDG 680 VYEGVAIGGD 690 RYPGSTFMDH 700 VLRYQDTPGV 710 KMIVVLGEIG 720 GTEEYKICRG 730 IKEGRLTKPV 740 VCWCIGTCAT 750 MFSSEVQFGH 760 AGACANQASE 770 TAVAKNQALK 780 EAGVFVPRSF 790 DELGEIIQSV 800 YEDLVAKGAI 810 VPAQEVPPPT 820 VPMDYSWARE 830 LGLIRKPASF 840 MTSICDERGQ 850 ELIYAGMPIT 860 EVFKEEMGIG 870 GVLGLLWFQR 880 RLPKYSCQFI 890 EMCLMVTADH 900 GPAVSGAHNT 910 IICARAGKDL 920 VSSLTSGLLT 930 IGDRFGGALD 940 AAAKMFSKAF 950 DSGIIPMEFV 960 NKMKKEGKLI 970 MGIGHRVKSI 980 NNPDMRVQIL 990 KDFVKQHFPA 1000 TPLLDYALEV 1010 EKITTSKKPN 1020 LILNVDGFIG 1030 VAFVDMLRNC 1040 GSFTREEADE 1050 YVDIGALNGV 1060 FVLGRSMGFI 1070 GHYLDQKRLK 1080 QGLYRHPWDD 1090 ISYVLPEHMS M

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0003878 ATP citrate synthase activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0006085 acetyl-CoA biosynthetic process
Biological Process GO:0006101 citrate metabolic process
Biological Process GO:0006629 lipid metabolic process

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.