Search Results

Overview

Uniprot ID	G3V9K0
Protein Name	Cysteine--tRNA ligase, cytoplasmic
Gene Name	Cars1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
10	GSSAEQGKGRRVQPQ
726	GQTKKLKKLFEAQEK

Function

Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys)

Protein Sequence

10 MAGSSAEQGK 20 GRRVQPQWSP 30 PAGTEPCRLR 40 LYNSLTRNKD 50 VFIPQDGKKV 60 TWYCCGPTVY 70 DASHMGHARS 80 YISFDILRRV 90 LRDYFQYDVF 100 YCMNITDIDD 110 KIIRRARQNY 120 LFEQYREQKP 130 SAAQLLKDVG 140 DAMKPFSVKL 150 SETTDPDKRQ 160 MLERIQNSVK 170 LATEPLEQAV 180 HSNPSGEEVD 190 SRVQVLLEEA 200 KDLLSDWLDS 210 TGGSEVTDNS 220 IFSKLPKFWE 230 EEFHKDMEAL 240 NVLPPDVLTR 250 VSEYVPEIVN 260 FVQKIVDNGY 270 GYASNGSVYF 280 DTAKFAASEK 290 HSYGKLVPEA 300 VGDQKALQEG 310 EGDLSISADR 320 LSEKRSPNDF 330 ALWKASKPGE 340 PSWPCPWGKG 350 RPGWHIECSA 360 MAGSLLGASM 370 DIHGGGFDLR 380 FPHHDNELAQ 390 SEAYFENDCW 400 VRYFLHTGHL 410 TIAGCKMSKS 420 LKNFITIKDA 430 LKKHSARQLR 440 LAFLMHSWKD 450 TLDYSSNTME 460 SALQYEKFMN 470 EFFLNVKDIL 480 RAPVDITGQF 490 EKWEAEEVEL 500 NKNFYDKKTA 510 VHEALCDNID 520 TRTVMEEMRA 530 LVSQCNLYMA 540 ARKAARRRPN 550 RALLENIAMY 560 LTHMLKIFGA 570 IEEENPLGFP 580 VGGPGTNLNL 590 ESTVMPYLQV 600 LSEFREGVRK 610 IAREKKVLEV 620 LQLSDALRDD 630 ILPELGVRFE 640 DHEGLPTVVK 650 LVDRDTLLKE 660 KEEKKRAEEE 670 KRRKKEEAAR 680 KKQEQEAAKL 690 AKMKTPPSEM 700 FRSETDKYSK 710 FDENGLPTHD 720 TEGKELSKGQ 730 TKKLKKLFEA 740 QEKVYKEYLQ QLQNSSLQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004817	cysteine-tRNA ligase activity
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006423	cysteinyl-tRNA aminoacylation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.