Search Results
Overview
| Uniprot ID | G3V9M1 |
|---|---|
| Protein Name | Probable ATP-dependent RNA helicase DDX23 |
| Gene Name | Ddx23 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 195 | EEERKKRKQFQDLGR |
Function
Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA
Protein Sequence
10
MAGELADKKD
20
RDASPKEERK
30
RSRTPERDRD
40
RDRDRKSSPS
50
KDRKRHRSRD
60
RRRGGSRSRS
70
RSRSKSTERE
80
RRHKERERDK
90
ERDRSKKERE
100
RDKDGHRRDK
110
DRKRSSLSPG
120
RGKDFKSRKD
130
RDSKKGDEDE
140
HGDKRPKIQP
150
LSLEELLAKK
160
KAEEEAEAKP
170
KFLSKAEREA
180
EALKRRQQEV
190
EERQKMLEEE
200
RKKRKQFQDL
210
GRKMLEDPQE
220
RERRERRERM
230
ERETNGNEDE
240
EGRQKIREEK
250
DKSKELHAIK
260
ERYLGGIKKR
270
RRTRHLNDRK
280
FVFEWDASED
290
TSIDYNPLYK
300
ERHQVQLLGR
310
GFIAGIDLKQ
320
QKREQSRFYG
330
DLMEKRRTLE
340
EKEQEEARLR
350
KLRKKEAKQR
360
WDDRHWSQKK
370
LDEMTDRDWR
380
IFREDYSITT
390
KGGKIPNPIR
400
SWKDSSLPPH
410
ILEVIDKCGY
420
KEPTPIQRQA
430
IPIGLQNRDI
440
IGVAETGSGK
450
TAAFLIPLLV
460
WITTLPKIDR
470
IEESDQGPYA
480
IILAPTRELA
490
QQIEEETIKF
500
GKPLGIRTVA
510
VIGGISREDQ
520
GFRLRMGCEI
530
VIATPGRLID
540
VLENRYLVLS
550
RCTYVVLDEA
560
DRMIDMGFEP
570
DVQKILEHMP
580
VSNQKPDTDE
590
AEDPEKMLAN
600
FESGKHKYRQ
610
TVMFTATMPP
620
AVERLARSYL
630
RRPAVVYIGS
640
AGKPHERVEQ
650
KVFLMSESEK
660
RKKLLAILEQ
670
GFDPPIIIFV
680
NQKKGCDVLA
690
KSLEKMGYNA
700
CTLHGGKGQE
710
QREFALSNLK
720
AGAKDILVAT
730
DVAGRGIDIQ
740
DVSMVVNYDM
750
AKNIEDYIHR
760
IGRTGRAGKS
770
GVAITFLTKE
780
DSAVFYELKQ
790
AILESPVSSC
800
PPELANHPDA
810
QHKPGTILTK
KRREETIFA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0071011 | precatalytic spliceosome |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0071016 | U12-type precatalytic spliceosome |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Cellular Component | GO:0005682 | U5 snRNP |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0003729 | mRNA binding |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0062176 | R-loop processing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.