Overview
| Uniprot ID | G3V9R8 |
|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein C |
|---|
| Gene Name | Hnrnpc |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 144 |
ARAVVPSKRQRVSGN |
| 163 |
GKSGFNSKSGQRGSS |
| 8 |
MASNVTNKTDPRSMN |
Function
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing
Protein Sequence
10
MASNVTNKTD
20
PRSMNSRVFI
30
GNLNTLVVKK
40
SDVEAIFSKY
50
GKIVGCSVHK
60
GFAFVQYVNE
70
RNARAAVAGE
80
DGRMIAGQVL
90
DINLAAEPKV
100
NRGKAGVKRS
110
AAEMYGSSFD
120
LDYDFQRDYY
130
DRMYSYPARV
140
PPPPPIARAV
150
VPSKRQRVSG
160
NTSRRGKSGF
170
NSKSGQRGSS
180
SKSVKGDDLQ
190
AIKKELTQIK
200
QKVDSLLESL
210
EKIEKEQSKQ
220
ADLSFSSPVE
230
MKNEKSEEEQ
240
SSASVKKDET
250
NVKMESEAGA
260
DDSAEEGDLL
270
DDDDNEDRGD
280
DQLELKDDEK
290
EPEEGEDDRD
SANGEDDS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015629 |
actin cytoskeleton |
| Cellular Component |
GO:0071013 |
catalytic step 2 spliceosome |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:1990826 |
nucleoplasmic periphery of the nuclear pore complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0045120 |
pronucleus |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0005681 |
spliceosomal complex |
| Cellular Component |
GO:0005697 |
telomerase holoenzyme complex |
| Molecular Function |
GO:1990827 |
deaminase binding |
| Molecular Function |
GO:0004857 |
enzyme inhibitor activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0003730 |
mRNA 3'-UTR binding |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:1990247 |
N6-methyladenosine-containing RNA reader activity |
| Molecular Function |
GO:0008266 |
poly(U) RNA binding |
| Molecular Function |
GO:0019904 |
protein domain specific binding |
| Molecular Function |
GO:0043021 |
ribonucleoprotein complex binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0070034 |
telomerase RNA binding |
| Biological Process |
GO:0070935 |
3'-UTR-mediated mRNA stabilization |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0090367 |
negative regulation of mRNA modification |
| Biological Process |
GO:0032211 |
negative regulation of telomere maintenance via telomerase |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.