Search Results
Overview
| Uniprot ID | G3V9W5 |
|---|---|
| Protein Name | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma |
| Gene Name | Pip4k2c |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 37 | KKHFVQQKVKVFRAA |
| 390 | KKAAHAAKTVKHGAG |
| 393 | AHAAKTVKHGAGAEI |
Function
Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3
Protein Sequence
10
MASSSVPPAT
20
APAAAGGPGP
30
GFGFASKTKK
40
KHFVQQKVKV
50
FRAADPLVGV
60
FLWGVAHSIN
70
ELSQVPPPVM
80
LLPDDFKASS
90
KIKVNNHLFH
100
RENLPSHFKF
110
KEYCPQVFRN
120
LRDRFAIDDH
130
DYLVSLTRSP
140
PSETEGSDGR
150
FLISYDRTLV
160
IKEVSSEDIA
170
DMHSNLSNYH
180
QYIVKCHGNT
190
LLPQFLGMYR
200
VSVENEDSYM
210
LVMRNMFSHR
220
LPVHRKYDLK
230
GSLVSREASD
240
KEKVKELPTL
250
KDMDFLNKNQ
260
KVYIGEEEKK
270
VFLEKLKRDV
280
EFLVQLKIMD
290
YSLLLGIHDI
300
IRGSEPEEEG
310
PVREEESEWD
320
GDCNLTGPPA
330
LVGSYGTSPE
340
GIGGYIHSHR
350
PLGPGEFESF
360
IDVYAIRSAE
370
GAPQKEVYFM
380
GLIDILTQYD
390
AKKKAAHAAK
400
TVKHGAGAEI
410
STVHPEQYAK
420
RFLDFISNIF
A
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005776 | autophagosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Molecular Function | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| Molecular Function | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:1902635 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| Biological Process | GO:0061909 | autophagosome-lysosome fusion |
| Biological Process | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| Biological Process | GO:2000786 | positive regulation of autophagosome assembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.