Search Results
Overview
| Uniprot ID | H0UTQ3 |
|---|---|
| Protein Name | Myosin-9 |
| Gene Name | MYH9 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1613 | SLAVAARKKLEMDLK |
Function
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis. Promotes cell motility in conjunction with S100A4. During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10
Protein Sequence
10
MAQQAADKYL
20
YVDKNFINNP
30
LAQADWAAKK
40
LVWVPSDKSG
50
FEPASLKEEV
60
GEEAIVELVE
70
NGKKVKVNKD
80
DIQKMNPPKF
90
SKVEDMAELT
100
CLNEASVLHN
110
LKERYYSGLI
120
YTYSGLFCVV
130
INPYKNLPIY
140
SEEIVEMYKG
150
KKRHEMPPHI
160
YAITDTAYRS
170
MMQDREDQSI
180
LCTGESGAGK
190
TENTKKVIQY
200
LAHVASSHKS
210
KKDQGELERQ
220
LLQANPILEA
230
FGNAKTVKND
240
NSSRFGKFIR
250
INFDVNGYIV
260
GANIETYLLE
270
KSRAIRQAKE
280
ERTFHIFYYL
290
LSGAGEHLKT
300
DLLLEPYNKY
310
RFLSNGHVTI
320
PGQQDKDMFQ
330
ETMEAMRIMG
340
IPEEEQMGLL
350
RVISGVLQLG
360
NIVFKKERNT
370
DQASMPDNTA
380
AQKVSHLLGI
390
NVTDFTRGIL
400
TPRIKVGRDY
410
VQKAQTKEQA
420
DFAIEALAKA
430
TYERMFRWLV
440
LRINKALDKT
450
KRQGASFIGI
460
LDIAGFEIFD
470
LNSFEQLCIN
480
YTNEKLQQLF
490
NHTMFILEQE
500
EYQREGIEWN
510
FIDFGLDLQP
520
CIDLIEKPAG
530
PPGILALLDE
540
ECWFPKATDK
550
SFVEKVMQEQ
560
GTHPKFQKPK
570
QLKDKADFCI
580
IHYAGKVDYK
590
ADEWLMKNMD
600
PLNDNIATLL
610
HQSSDKFVSE
620
LWKDVDRIIG
630
LDQVAGMSET
640
ALPGAFKTRK
650
GMFRTVGQLY
660
KEQLAKLMAT
670
LRNTNPNFVR
680
CIIPNHEKKA
690
GKLDPHLVLD
700
QLRCNGVLEG
710
IRICRQGFPN
720
RVVFQEFRQR
730
YEILTPNSIP
740
KGFMDGKQAC
750
VLMIKALELD
760
SNLYRIGQSK
770
VFFRAGVLAH
780
LEEERDLKIT
790
DVIIGFQACC
800
RGYLARKAFA
810
KRQQQLTAMK
820
VLQRNCAAYL
830
KLRNWQWWRL
840
FTKVKPLLQV
850
SRQEEEMLAK
860
EEELVKVREK
870
QLAAENKLTE
880
METLQSQLMA
890
EKLQLQEQLQ
900
AETELCAEAE
910
ELRARLTAKK
920
QELEEICHDL
930
EARVEEEEER
940
CQHLQAEKKK
950
MQQNIQELEE
960
QLEEEESARQ
970
KLQLEKVTTE
980
AKLKKLEEDQ
990
IIMEDQNCKL
1000
AKEKKLLEDR
1010
IAEFTTNLME
1020
EEEKSKSLAK
1030
LKNKHEAMIT
1040
DLEERLRREE
1050
KQRQELEKTR
1060
RKLEGDSTDL
1070
SDQIAELQAQ
1080
IAELKMQLAK
1090
KEEELQTALA
1100
RVEEEAAQKN
1110
MALKKIRELE
1120
SQISELQEDL
1130
ESERASRNKA
1140
EKQKRDLGEE
1150
LEALKTELED
1160
TLDSTAAQQE
1170
LRSKREQEVN
1180
ILKKTLEEEA
1190
RTHEAQIQEM
1200
RQKHSQAVEE
1210
LAEQLEQTKR
1220
VKATLEKAKQ
1230
TLENERGELA
1240
NEVKVLMQGK
1250
GDSEHKRKKV
1260
EAQLQELQVK
1270
FNEGERVRTE
1280
LADKVTKLQV
1290
ELDNVTGLLN
1300
QSDSKSSKLT
1310
KDFSALESQL
1320
QDTQELLQEE
1330
NRQKLSLSTK
1340
LKQMEDEKNS
1350
FKEQLEEEEE
1360
AKHNLEKQIA
1370
TLQAQVTDMK
1380
KKMEDGVGCL
1390
ETSEEARRKL
1400
QKDLEGLSQR
1410
HEEKVAAYDK
1420
LEKTKTRLQQ
1430
ELDDLLVDLD
1440
HQRQSVSNLE
1450
KKQKKFDQLL
1460
AEEKTISAKY
1470
AEERDRAEAE
1480
AREKETKALS
1490
LARALEEAME
1500
QKAELERLNK
1510
QFRTEMEDLM
1520
SSKDDVGKSV
1530
HELEKSKRAL
1540
EQQVEEMKTQ
1550
LEELEDELQA
1560
TEDAKLRLEV
1570
NLQAMKAQFE
1580
RDLQGRDEQS
1590
EEKKKQLVRQ
1600
VREMEAELED
1610
EKKQRSLAVA
1620
ARKKLEMDLK
1630
DLEAHIDTAN
1640
KNREEAIKQL
1650
RKLQAQMKDC
1660
MRELEDTRAS
1670
REEILAQAKE
1680
NEKKLKSMEA
1690
EMIQLQEELA
1700
AAERAKRQAQ
1710
QERDELADEI
1720
ANSSGKGALA
1730
LEEKRRLEAR
1740
IAQLEEELEE
1750
EQGNTELIND
1760
RLKKANLQID
1770
QINTDLNLER
1780
SHAQKNENAR
1790
QQLERQNKEL
1800
KVKLQEMEGT
1810
VKSKYKASIT
1820
ALEAKIAQLE
1830
EQLDNETKER
1840
QAASKQVRRA
1850
EKRLKDVLLQ
1860
VEDERRNAEQ
1870
YKDQADKAST
1880
RLKQLKRQLE
1890
EAEEEAQRAN
1900
ASRRKLQREL
1910
EDATETADAM
1920
NREVSSLKNK
1930
LRRGDMPFVV
1940
PRRMARKGTG
1950
DCSDEEVDGK
1960
ADGAEAKPTE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005826 | actomyosin contractile ring |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0032154 | cleavage furrow |
| Cellular Component | GO:0008180 | COP9 signalosome |
| Cellular Component | GO:0060473 | cortical granule |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0001772 | immunological synapse |
| Cellular Component | GO:0016460 | myosin II complex |
| Cellular Component | GO:0097513 | myosin II filament |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0005819 | spindle |
| Cellular Component | GO:0001725 | stress fiber |
| Cellular Component | GO:0001931 | uropod |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0043531 | ADP binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0000146 | microfilament motor activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0043495 | protein-membrane adaptor activity |
| Molecular Function | GO:0001618 | virus receptor activity |
| Biological Process | GO:0030048 | actin filament-based movement |
| Biological Process | GO:0031032 | actomyosin structure organization |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0043534 | blood vessel endothelial cell migration |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0060471 | cortical granule exocytosis |
| Biological Process | GO:0032506 | cytokinetic process |
| Biological Process | GO:0032418 | lysosome localization |
| Biological Process | GO:0006509 | membrane protein ectodomain proteolysis |
| Biological Process | GO:0030224 | monocyte differentiation |
| Biological Process | GO:1903919 | negative regulation of actin filament severing |
| Biological Process | GO:0006911 | phagocytosis, engulfment |
| Biological Process | GO:0001778 | plasma membrane repair |
| Biological Process | GO:0030220 | platelet formation |
| Biological Process | GO:1903923 | positive regulation of protein processing in phagocytic vesicle |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:1905684 | regulation of plasma membrane repair |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.