Search Results
Overview
| Uniprot ID | H0UTZ2 |
|---|---|
| Protein Name | Core histone macro-H2A |
| Gene Name | MACROH2A1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 123 | KKRGSKGKLEAIITP |
| 134 | IITPPPAKKAKSPSQ |
| 166 | KKQGEVSKAASADST |
| 18 | TKTSRSAKAGVIFPV |
| 303 | CLALADDKKLKSIAF |
Function
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes
Protein Sequence
10
MSSRGGKKKS
20
TKTSRSAKAG
30
VIFPVGRMLR
40
YIKKGHPKYR
50
IGVGAPVYMA
60
AVLEYLTAEI
70
LELAGNAARD
80
NKKGRVTPRH
90
ILLAVANDEE
100
LNQLLKGVTI
110
ASGGVLPNIH
120
PELLAKKRGS
130
KGKLEAIITP
140
PPAKKAKSPS
150
QKKPVSKKTG
160
GKKGARKSKK
170
QGEVSKAASA
180
DSTTEGTPAD
190
GFTVLSTKSL
200
FLGQKLNLIH
210
SEISNLAGFE
220
VEAIINPTNA
230
DIDLKDDLGN
240
TLEKKGGKEF
250
VEAVLELRKK
260
NGPLEVAGAA
270
VSAGHGLPAK
280
FVIHCNSPVW
290
GADKCEELLE
300
KTVKNCLALA
310
DDKKLKSIAF
320
PSIGSGRNGF
330
PKQTAAQLIL
340
KAISSYFVST
350
MSSSIKTVYF
360
VLFDSESIGI
370
YVQEMAKLDT
N
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001740 | Barr body |
| Cellular Component | GO:0000793 | condensed chromosome |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005721 | pericentric heterochromatin |
| Cellular Component | GO:0090734 | site of DNA damage |
| Molecular Function | GO:0160002 | ADP-D-ribose modification-dependent protein binding |
| Molecular Function | GO:0010385 | double-stranded methylated DNA binding |
| Molecular Function | GO:0031492 | nucleosomal DNA binding |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030291 | protein serine/threonine kinase inhibitor activity |
| Molecular Function | GO:0000182 | rDNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0071169 | establishment of protein localization to chromatin |
| Biological Process | GO:1902750 | negative regulation of cell cycle G2/M phase transition |
| Biological Process | GO:0045814 | negative regulation of gene expression, epigenetic |
| Biological Process | GO:1904815 | negative regulation of protein localization to chromosome, telomeric region |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:1901837 | negative regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:1903226 | positive regulation of endodermal cell differentiation |
| Biological Process | GO:0045618 | positive regulation of keratinocyte differentiation |
| Biological Process | GO:0034184 | positive regulation of maintenance of mitotic sister chromatid cohesion |
| Biological Process | GO:0019216 | regulation of lipid metabolic process |
| Biological Process | GO:1902688 | regulation of NAD metabolic process |
| Biological Process | GO:0002082 | regulation of oxidative phosphorylation |
| Biological Process | GO:1902882 | regulation of response to oxidative stress |
| Biological Process | GO:0045815 | transcription initiation-coupled chromatin remodeling |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.