Search Results
Overview
| Uniprot ID | H0UUD0 |
|---|---|
| Protein Name | Solute carrier family 2, facilitated glucose transporter member 1 |
| Gene Name | SLC2A1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 256 | RQMMREKKVTILELF |
Function
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. Required for mesendoderm differentiation
Protein Sequence
10
MEPSSKKVTG
20
RLMLSVGGAV
30
LGSLQFGYNT
40
GVINAPQKVI
50
EEFYNQTWIH
60
RYGEPILPTT
70
LTTLWSLSVA
80
IFSVGGMIGS
90
FSVGLFVNRF
100
GRRNSMLMMN
110
LLAFLSAVLM
120
GFSKLGKSFE
130
MLILGRFIIG
140
VYCGLTTGFV
150
PMYVGEVSPT
160
ALRGALGTLH
170
QLGIVVGILV
180
AQVFGLDSIM
190
GNEELWPLLL
200
SVIFAPALLQ
210
CVLLPFCPES
220
PRFLLINRNE
230
ENRAKSVLKK
240
LRGTADVSQD
250
LQEMKEESRQ
260
MMREKKVTIL
270
ELFRSPAYRQ
280
PILIAVVLQL
290
SQQLSGINAV
300
FYYSTSIFEK
310
AGVQQPVYAT
320
IGSGIVNTAF
330
TVVSLFVVER
340
AGRRTLHLIG
350
LGGMAGCAVL
360
MTIALALLEQ
370
LSWMSYLSIV
380
AIFGFVAFFE
390
VGPGPIPWFI
400
VAELFSQGPR
410
PAAFAVSGFS
420
NWTSNFIVGM
430
CFQYVEQLCG
440
PYVFIIFTVL
450
LILFFIFTYF
460
KVPETKGRTF
470
DEIASGFRQG
480
GANPSDKTPE
490
ELFRPLGADS
QV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0001939 | female pronucleus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0055056 | D-glucose transmembrane transporter activity |
| Molecular Function | GO:0033300 | dehydroascorbic acid transmembrane transporter activity |
| Molecular Function | GO:0015150 | fucose transmembrane transporter activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005324 | long-chain fatty acid transmembrane transporter activity |
| Biological Process | GO:0098708 | D-glucose import across plasma membrane |
| Biological Process | GO:0015911 | long-chain fatty acid import across plasma membrane |
| Biological Process | GO:0045494 | photoreceptor cell maintenance |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0032868 | response to insulin |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.