Overview
| Uniprot ID | H0UUH5 |
|---|
| Protein Name | Craniofacial development protein 1 |
|---|
| Gene Name | CFDP1 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 144 |
TEETTSSKSLIKTEE |
| 165 |
AEKVKITKVFDFAGE |
| 192 |
KEAKSFFKQNEKEKP |
| 228 |
GMSSLLGKIGAKKQK |
| 235 |
KIGAKKQKMSTLEKS |
| 54 |
KTKGKKRKTQSIPAR |
| 64 |
SIPARKRKQSCLLLE |
Function
Required for the structural stability of pericentromeric heterochromatin. Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites and is required for incorporation of histone H2AZ1/H2AZ into chromatin. Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats. Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis. Plays a role in craniofacial development. Required to maintain normal cell function in embryonic development
Protein Sequence
10
MEEFDSEDFS
20
TSEEDEDYVP
30
SGGEYSEDDV
40
NELVKEDEVD
50
GEEQTQKTKG
60
KKRKTQSIPA
70
RKRKQSCLLL
80
EDEEEDAKTK
90
SGGSSSEEDG
100
VGEVEKGTGP
110
EDARRKKEDE
120
LWASFLNDVG
130
PKSKVPPSTQ
140
AKTEEQTEET
150
TSSKSLIKTE
160
ELEKPKEAEK
170
VKITKVFDFA
180
GEEVRVTKEV
190
DATSKEAKSF
200
FKQNEKEKPQ
210
SSAPLAAPSL
220
SAGPGLKRSS
230
GMSSLLGKIG
240
AKKQKMSTLE
250
KSKLDWESFK
260
EEEGIGEELA
270
IHNRGKEGYI
280
ERKAFLERVD
290
HRQFEIERDL
RLSKMKP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0000812 |
Swr1 complex |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.