Search Results

Overview

Uniprot IDH0UUV6
Protein NameNuclear receptor corepressor 1
Gene NameNCOR1
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
1159 GREEAASKGHVIYEG
1196 TAHEISLKRSYESVE
1346 SSGQSAIKHNVKSLI
1350 SAIKHNVKSLITGPS
1358 SLITGPSKLPRGMPP
1457 EVTISSSKSANHERK
199 KVEQQILKLKKKQQQ
681 DNLLQQHKQKVSVTV

Function

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver

Protein Sequence

10 MSSSGYPPNQ 20 GAFSTEQSRY 30 PSHSVQYTFP 40 NTRHQQEFAV 50 PDYRSSHLEV 60 SQASQLLQQQ 70 QQLRRRPSLL 80 SEFHPGSDRP 90 QERRSGYEQF 100 HPGPSPVDHD 110 SLESKRPRLE 120 QVTDSHFQRV 130 SAAVLPLVHT 140 LPEGLRSSAD 150 PKKDSAFGGK 160 HEAPSSPISG 170 QQCGDDQNAS 180 PSKLSKEELI 190 QSMDRVDREI 200 AKVEQQILKL 210 KKKQQQLEEE 220 AAKPPEPEKP 230 VSPPPVEQKH 240 RSIVQIIYDE 250 NRKKAEEAHK 260 IFEGLGPKVE 270 LPLYNQPSDT 280 KVYHENIKTN 290 QVMRKKLILF 300 FKRRNHARKQ 310 REQKICQRYD 320 QLMEAWEKKV 330 DRIENNPRRK 340 AKESKTREYY 350 EKQFPEIRKQ 360 REQQERFQRV 370 GQRGAGLSAT 380 IARSEHEISE 390 IIDGLSEQEN 400 NEKQMRQLSV 410 IPPMMFDAEQ 420 RRVKFINMNG 430 LMEDPMKVYK 440 DRQFMNVWTD 450 HEKEIFKDKF 460 IQHPKNFGLI 470 ASYLERKSVP 480 DCVLYYYLTK 490 KNENYKALVR 500 RNYGKRRGRN 510 QQIARPSQEE 520 KVEEKEEDKA 530 EKTDKKEEEK 540 KEEEEKDEKE 550 DSKENTKEKD 560 KTEGTTEETE 570 EREQATPRGR 580 KTANSQGRRK 590 GRITRSMTNE 600 AAAASAAAAA 610 ATEEPPPPLP 620 PPPEPVPTEP 630 VETSRWTEEE 640 MEVAKKGLVE 650 HGRNWAAIAK 660 MVGTKSEAQC 670 KNFYFNYKRR 680 HNLDNLLQQH 690 KQKVSVTVVP 700 SEDSSENAAS 710 RGTTEPVAEL 720 ETTSEPAPAT 730 SPSLAAPSTK 740 PAESEKVETQ 750 ADDSSCAETA 760 EPMDVDHQER 770 SAEGESVLDP 780 PATTKEDSVD 790 VEMGAPENSA 800 STDEGDAKER 810 DLERGSEKTE 820 PGDEDLVVAQ 830 QISTQRPEPQ 840 SDNDSSATCS 850 ADEDVDGEPE 860 RQRMFPMDPK 870 PSLLNPAGSV 880 LVSSPAKANP 890 LDLPQLQHRA 900 AVIPPMVSCT 910 PCSIPIGTPV 920 SGYALYQRHI 930 KAMHESALLE 940 EQRQRQEQID 950 LECRSSTSPC 960 GTSKSPNREW 970 EVLQPAPHQV 980 ITNLPEGVRL 990 STTRPTRPPP 1000 PLIPSSKTTV 1010 ASEKPSFIMG 1020 GSISQGTPGT 1030 YLTSHNQASY 1040 PQETAKPSVG 1050 SISLGLPRQQ 1060 ESTKSATLPY 1070 IKQEEFSPRS 1080 QNSQPEGLLV 1090 RAQHEGTTGA 1100 IQEGSITRGT 1110 PTSKISVESI 1120 PSLRGSITQG 1130 TPALSQAGIP 1140 TEALMKGSIS 1150 RMSIEESSPE 1160 KGREEAASKG 1170 HVIYEGKSGH 1180 ILSYDNIKNA 1190 REGTRSPRTA 1200 HEISLKRSYE 1210 SVEGNIKQLN 1220 FILVSKGLIC 1230 RALPRGSPHS 1240 DLKERTVLSG 1250 SIMQGTPRAT 1260 SEAFEDGLKY 1270 PKQIKRESPP 1280 IRAFEGAITK 1290 GKPYDGITTI 1300 KEMGRSIHEI 1310 PRQDILTQES 1320 RKTPEVVQNT 1330 RPIIEGSISQ 1340 GTPIKFDSSS 1350 GQSAIKHNVK 1360 SLITGPSKLP 1370 RGMPPLEIVP 1380 ESIKVVERGK 1390 YEDVKAGEPV 1400 RSRHTSVVSS 1410 GPSVLRSTLH 1420 EAPKAQLSPG 1430 IYDDSSARRT 1440 PVSYQNTMSR 1450 GSPMMNRTSE 1460 VTISSSKSAN 1470 HERKSTLTPT 1480 QRESISAKSP 1490 VPGVDPVVSH 1500 SPFDPHHRGS 1510 TAGEVYRSHL 1520 PTHLDPAMPF 1530 HRALDPAAAA 1540 YLFQRQLSPT 1550 PGYPSQYQLY 1560 AMENTRQTIL 1570 NDYITSQQMQ 1580 VNLRPDVARG 1590 LSPREQPLGL 1600 PYPATRGIID 1610 LTNMPPAILV 1620 PHPGGTSTPP 1630 MDRITYIPGT 1640 QITFPPRPYN 1650 SASMSPGHST 1660 HLAAAASAER 1670 ERERERERER 1680 EREKERERER 1690 ERERMAVASS 1700 DLYLRPGTEQ 1710 PGRPGSHGYV 1720 RSPSPSLRTQ 1730 ETMLQQRPSV 1740 FQGTNGTSVI 1750 TPLDPTAQLR 1760 IMPLPAGGPS 1770 ISQGLPASRY 1780 NTAADALAAL 1790 VDAAASAPQM 1800 DVSKTKESKH 1810 EAARLEENLR 1820 SRSAAVSEQQ 1830 QLEQKSLEVE 1840 KRSVQCLYTS 1850 SAFPSGKPQP 1860 HASVVYSEAG 1870 KDKGPPPKSR 1880 YEEELRTRGK 1890 TTITAANFID 1900 VIITRQIASD 1910 KDARERGSQS 1920 SDSSSSLSSH 1930 RYETPSDAIE 1940 VVSPASSPAP 1950 SQEKLQTYQP 1960 EIVKANQTES 1970 TSATPPQYEG 1980 PLHHYRPQQE 1990 SPSPQQQLPP 2000 SSQADGIGQV 2010 PRTHRLITLA 2020 DHICQIITQD 2030 FARNQQPPTS 2040 TFQNSPSALV 2050 STPVRAKTSS 2060 RYSPESQSQS 2070 VLHQRPGSRV 2080 SPENLVDKSR 2090 GRPGKSPERS 2100 HVSSEPYEPI 2110 SPPQVPVVHE 2120 KQDSMLLLSQ 2130 RGVESAEQRN 2140 DSRSPGSISY 2150 LPSFFTKLEN 2160 TSPMVKSKKQ 2170 EIFRKLNSSG 2180 GGDSDMAAAQ 2190 PGTEIFNLPA 2200 VTTSGAVSSR 2210 SHSFADPASN 2220 LGLEDIIRKA 2230 LMGSFDDKVE 2240 DHGVVISQPV 2250 GVVPGSASTS 2260 LVTSSEARRD 2270 EGDPSPLSGV 2280 CKPKLISKSS 2290 NRKSKSPIPG 2300 QGYLGAERPS 2310 SVSSVHSEGD 2320 YHRQTPGWTW 2330 EDRPSSTGST 2340 QFPYNPLTMR 2350 MLSSTPPTPI 2360 ACAPSAVTQA 2370 VPHQQTRIWE 2380 REPAPLLSAQ YETLSDSDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0046966 nuclear thyroid hormone receptor binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0061436 establishment of skin barrier
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0060766 negative regulation of androgen receptor signaling pathway
Biological Process GO:0045922 negative regulation of fatty acid metabolic process
Biological Process GO:0045820 negative regulation of glycolytic process
Biological Process GO:0046329 negative regulation of JNK cascade
Biological Process GO:1902894 negative regulation of miRNA transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0050821 protein stabilization
Biological Process GO:0048511 rhythmic process
Biological Process GO:0051225 spindle assembly

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.