Overview
| Uniprot ID | H0UUV6 |
| Protein Name | Nuclear receptor corepressor 1 |
| Gene Name | NCOR1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 1159 |
GREEAASKGHVIYEG |
| 1196 |
TAHEISLKRSYESVE |
| 1346 |
SSGQSAIKHNVKSLI |
| 1350 |
SAIKHNVKSLITGPS |
| 1358 |
SLITGPSKLPRGMPP |
| 1457 |
EVTISSSKSANHERK |
| 199 |
KVEQQILKLKKKQQQ |
| 681 |
DNLLQQHKQKVSVTV |
Function
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver
Protein Sequence
10
MSSSGYPPNQ
20
GAFSTEQSRY
30
PSHSVQYTFP
40
NTRHQQEFAV
50
PDYRSSHLEV
60
SQASQLLQQQ
70
QQLRRRPSLL
80
SEFHPGSDRP
90
QERRSGYEQF
100
HPGPSPVDHD
110
SLESKRPRLE
120
QVTDSHFQRV
130
SAAVLPLVHT
140
LPEGLRSSAD
150
PKKDSAFGGK
160
HEAPSSPISG
170
QQCGDDQNAS
180
PSKLSKEELI
190
QSMDRVDREI
200
AKVEQQILKL
210
KKKQQQLEEE
220
AAKPPEPEKP
230
VSPPPVEQKH
240
RSIVQIIYDE
250
NRKKAEEAHK
260
IFEGLGPKVE
270
LPLYNQPSDT
280
KVYHENIKTN
290
QVMRKKLILF
300
FKRRNHARKQ
310
REQKICQRYD
320
QLMEAWEKKV
330
DRIENNPRRK
340
AKESKTREYY
350
EKQFPEIRKQ
360
REQQERFQRV
370
GQRGAGLSAT
380
IARSEHEISE
390
IIDGLSEQEN
400
NEKQMRQLSV
410
IPPMMFDAEQ
420
RRVKFINMNG
430
LMEDPMKVYK
440
DRQFMNVWTD
450
HEKEIFKDKF
460
IQHPKNFGLI
470
ASYLERKSVP
480
DCVLYYYLTK
490
KNENYKALVR
500
RNYGKRRGRN
510
QQIARPSQEE
520
KVEEKEEDKA
530
EKTDKKEEEK
540
KEEEEKDEKE
550
DSKENTKEKD
560
KTEGTTEETE
570
EREQATPRGR
580
KTANSQGRRK
590
GRITRSMTNE
600
AAAASAAAAA
610
ATEEPPPPLP
620
PPPEPVPTEP
630
VETSRWTEEE
640
MEVAKKGLVE
650
HGRNWAAIAK
660
MVGTKSEAQC
670
KNFYFNYKRR
680
HNLDNLLQQH
690
KQKVSVTVVP
700
SEDSSENAAS
710
RGTTEPVAEL
720
ETTSEPAPAT
730
SPSLAAPSTK
740
PAESEKVETQ
750
ADDSSCAETA
760
EPMDVDHQER
770
SAEGESVLDP
780
PATTKEDSVD
790
VEMGAPENSA
800
STDEGDAKER
810
DLERGSEKTE
820
PGDEDLVVAQ
830
QISTQRPEPQ
840
SDNDSSATCS
850
ADEDVDGEPE
860
RQRMFPMDPK
870
PSLLNPAGSV
880
LVSSPAKANP
890
LDLPQLQHRA
900
AVIPPMVSCT
910
PCSIPIGTPV
920
SGYALYQRHI
930
KAMHESALLE
940
EQRQRQEQID
950
LECRSSTSPC
960
GTSKSPNREW
970
EVLQPAPHQV
980
ITNLPEGVRL
990
STTRPTRPPP
1000
PLIPSSKTTV
1010
ASEKPSFIMG
1020
GSISQGTPGT
1030
YLTSHNQASY
1040
PQETAKPSVG
1050
SISLGLPRQQ
1060
ESTKSATLPY
1070
IKQEEFSPRS
1080
QNSQPEGLLV
1090
RAQHEGTTGA
1100
IQEGSITRGT
1110
PTSKISVESI
1120
PSLRGSITQG
1130
TPALSQAGIP
1140
TEALMKGSIS
1150
RMSIEESSPE
1160
KGREEAASKG
1170
HVIYEGKSGH
1180
ILSYDNIKNA
1190
REGTRSPRTA
1200
HEISLKRSYE
1210
SVEGNIKQLN
1220
FILVSKGLIC
1230
RALPRGSPHS
1240
DLKERTVLSG
1250
SIMQGTPRAT
1260
SEAFEDGLKY
1270
PKQIKRESPP
1280
IRAFEGAITK
1290
GKPYDGITTI
1300
KEMGRSIHEI
1310
PRQDILTQES
1320
RKTPEVVQNT
1330
RPIIEGSISQ
1340
GTPIKFDSSS
1350
GQSAIKHNVK
1360
SLITGPSKLP
1370
RGMPPLEIVP
1380
ESIKVVERGK
1390
YEDVKAGEPV
1400
RSRHTSVVSS
1410
GPSVLRSTLH
1420
EAPKAQLSPG
1430
IYDDSSARRT
1440
PVSYQNTMSR
1450
GSPMMNRTSE
1460
VTISSSKSAN
1470
HERKSTLTPT
1480
QRESISAKSP
1490
VPGVDPVVSH
1500
SPFDPHHRGS
1510
TAGEVYRSHL
1520
PTHLDPAMPF
1530
HRALDPAAAA
1540
YLFQRQLSPT
1550
PGYPSQYQLY
1560
AMENTRQTIL
1570
NDYITSQQMQ
1580
VNLRPDVARG
1590
LSPREQPLGL
1600
PYPATRGIID
1610
LTNMPPAILV
1620
PHPGGTSTPP
1630
MDRITYIPGT
1640
QITFPPRPYN
1650
SASMSPGHST
1660
HLAAAASAER
1670
ERERERERER
1680
EREKERERER
1690
ERERMAVASS
1700
DLYLRPGTEQ
1710
PGRPGSHGYV
1720
RSPSPSLRTQ
1730
ETMLQQRPSV
1740
FQGTNGTSVI
1750
TPLDPTAQLR
1760
IMPLPAGGPS
1770
ISQGLPASRY
1780
NTAADALAAL
1790
VDAAASAPQM
1800
DVSKTKESKH
1810
EAARLEENLR
1820
SRSAAVSEQQ
1830
QLEQKSLEVE
1840
KRSVQCLYTS
1850
SAFPSGKPQP
1860
HASVVYSEAG
1870
KDKGPPPKSR
1880
YEEELRTRGK
1890
TTITAANFID
1900
VIITRQIASD
1910
KDARERGSQS
1920
SDSSSSLSSH
1930
RYETPSDAIE
1940
VVSPASSPAP
1950
SQEKLQTYQP
1960
EIVKANQTES
1970
TSATPPQYEG
1980
PLHHYRPQQE
1990
SPSPQQQLPP
2000
SSQADGIGQV
2010
PRTHRLITLA
2020
DHICQIITQD
2030
FARNQQPPTS
2040
TFQNSPSALV
2050
STPVRAKTSS
2060
RYSPESQSQS
2070
VLHQRPGSRV
2080
SPENLVDKSR
2090
GRPGKSPERS
2100
HVSSEPYEPI
2110
SPPQVPVVHE
2120
KQDSMLLLSQ
2130
RGVESAEQRN
2140
DSRSPGSISY
2150
LPSFFTKLEN
2160
TSPMVKSKKQ
2170
EIFRKLNSSG
2180
GGDSDMAAAQ
2190
PGTEIFNLPA
2200
VTTSGAVSSR
2210
SHSFADPASN
2220
LGLEDIIRKA
2230
LMGSFDDKVE
2240
DHGVVISQPV
2250
GVVPGSASTS
2260
LVTSSEARRD
2270
EGDPSPLSGV
2280
CKPKLISKSS
2290
NRKSKSPIPG
2300
QGYLGAERPS
2310
SVSSVHSEGD
2320
YHRQTPGWTW
2330
EDRPSSTGST
2340
QFPYNPLTMR
2350
MLSSTPPTPI
2360
ACAPSAVTQA
2370
VPHQQTRIWE
2380
REPAPLLSAQ
YETLSDSDD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000118 |
histone deacetylase complex |
| Cellular Component |
GO:0072686 |
mitotic spindle |
| Cellular Component |
GO:0017053 |
transcription repressor complex |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0042826 |
histone deacetylase binding |
| Molecular Function |
GO:0046966 |
nuclear thyroid hormone receptor binding |
| Molecular Function |
GO:0003714 |
transcription corepressor activity |
| Biological Process |
GO:0006325 |
chromatin organization |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0061436 |
establishment of skin barrier |
| Biological Process |
GO:0001701 |
in utero embryonic development |
| Biological Process |
GO:0060766 |
negative regulation of androgen receptor signaling pathway |
| Biological Process |
GO:0045922 |
negative regulation of fatty acid metabolic process |
| Biological Process |
GO:0045820 |
negative regulation of glycolytic process |
| Biological Process |
GO:0046329 |
negative regulation of JNK cascade |
| Biological Process |
GO:1902894 |
negative regulation of miRNA transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0050821 |
protein stabilization |
| Biological Process |
GO:0048511 |
rhythmic process |
| Biological Process |
GO:0051225 |
spindle assembly |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.